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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JMIR Human Factors</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Hum Factors</journal-id>
      <journal-title>JMIR Human Factors</journal-title>
      <issn pub-type="epub">2292-9495</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v9i4e38799</article-id>
      <article-id pub-id-type="pmid">36459412</article-id>
      <article-id pub-id-type="doi">10.2196/38799</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Paper</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Original Paper</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Public Trust in Artificial Intelligence Applications in Mental Health Care: Topic Modeling Analysis</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Kushniruk</surname>
            <given-names>Andre</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Huang</surname>
            <given-names>Jian</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Borycki</surname>
            <given-names>Elizabeth</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Shan</surname>
            <given-names>Yi</given-names>
          </name>
          <degrees>Prof Dr</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Nantong University</institution>
            <addr-line>No 9, Seyuan Rd</addr-line>
            <addr-line>Nantong, 226019</addr-line>
            <country>China</country>
            <phone>86 15558121896</phone>
            <email>victorsyhz@hotmail.com</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-3168-1585</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Ji</surname>
            <given-names>Meng</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-7463-9208</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Xie</surname>
            <given-names>Wenxiu</given-names>
          </name>
          <degrees>MPhil</degrees>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-8528-5193</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Lam</surname>
            <given-names>Kam-Yiu</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-0673-3566</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Chow</surname>
            <given-names>Chi-Yin</given-names>
          </name>
          <degrees>PhD</degrees>
          <xref rid="aff3" ref-type="aff">3</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-9566-0743</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Nantong University</institution>
        <addr-line>Nantong</addr-line>
        <country>China</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>University of Sydney</institution>
        <addr-line>Sydney</addr-line>
        <country>Australia</country>
      </aff>
      <aff id="aff3">
        <label>3</label>
        <institution>City University of Hong Kong</institution>
        <addr-line>Hong Kong</addr-line>
        <country>China</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Yi Shan <email>victorsyhz@hotmail.com</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <season>Oct-Dec</season>
        <year>2022</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>2</day>
        <month>12</month>
        <year>2022</year>
      </pub-date>
      <volume>9</volume>
      <issue>4</issue>
      <elocation-id>e38799</elocation-id>
      <history>
        <date date-type="received">
          <day>16</day>
          <month>4</month>
          <year>2022</year>
        </date>
        <date date-type="rev-request">
          <day>28</day>
          <month>6</month>
          <year>2022</year>
        </date>
        <date date-type="rev-recd">
          <day>10</day>
          <month>7</month>
          <year>2022</year>
        </date>
        <date date-type="accepted">
          <day>9</day>
          <month>11</month>
          <year>2022</year>
        </date>
      </history>
      <copyright-statement>©Yi Shan, Meng Ji, Wenxiu Xie, Kam-Yiu Lam, Chi-Yin Chow. Originally published in JMIR Human Factors (https://humanfactors.jmir.org), 02.12.2022.</copyright-statement>
      <copyright-year>2022</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Human Factors, is properly cited. The complete bibliographic information, a link to the original publication on https://humanfactors.jmir.org, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://humanfactors.jmir.org/2022/4/e38799" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>Mental disorders (MDs) impose heavy burdens on health care (HC) systems and affect a growing number of people worldwide. The use of mobile health (mHealth) apps empowered by artificial intelligence (AI) is increasingly being resorted to as a possible solution.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This study adopted a topic modeling (TM) approach to investigate the public trust in AI apps in mental health care (MHC) by identifying the dominant topics and themes in user reviews of the 8 most relevant mental health (MH) apps with the largest numbers of reviewers.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>We searched Google Play for the top MH apps with the largest numbers of reviewers, from which we selected the most relevant apps. Subsequently, we extracted data from user reviews posted from January 1, 2020, to April 2, 2022. After cleaning the extracted data using the Python text processing tool spaCy, we ascertained the optimal number of topics, drawing on the coherence scores and used latent Dirichlet allocation (LDA) TM to generate the most salient topics and related terms. We then classified the ascertained topics into different theme categories by plotting them onto a 2D plane via multidimensional scaling using the pyLDAvis visualization tool. Finally, we analyzed these topics and themes qualitatively to better understand the status of public trust in AI apps in MHC.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>From the top 20 MH apps with the largest numbers of reviewers retrieved, we chose the 8 (40%) most relevant apps: (1) Wysa: Anxiety Therapy Chatbot; (2) Youper Therapy; (3) MindDoc: Your Companion; (4) TalkLife for Anxiety, Depression &#38; Stress; (5) 7 Cups: Online Therapy for Mental Health &#38; Anxiety; (6) BetterHelp-Therapy; (7) Sanvello; and (8) InnerHour. These apps provided 14.2% (n=559), 11.0% (n=431), 13.7% (n=538), 8.8% (n=356), 14.1% (n=554), 11.9% (n=468), 9.2% (n=362), and 16.9% (n=663) of the collected 3931 reviews, respectively. The 4 dominant topics were topic 4 (cheering people up; n=1069, 27%), topic 3 (calming people down; n=1029, 26%), topic 2 (helping figure out the inner world; n=963, 25%), and topic 1 (being an alternative or complement to a therapist; n=870, 22%). Based on topic coherence and intertopic distance, topics 3 and 4 were combined into theme 3 (dispelling negative emotions), while topics 2 and 1 remained 2 separate themes: theme 2 (helping figure out the inner world) and theme 1 (being an alternative or complement to a therapist), respectively. These themes and topics, though involving some dissenting voices, reflected an overall high status of trust in AI apps.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>This is the first study to investigate the public trust in AI apps in MHC from the perspective of user reviews using the TM technique. The automatic text analysis and complementary manual interpretation of the collected data allowed us to discover the dominant topics hidden in a data set and categorize these topics into different themes to reveal an overall high degree of public trust. The dissenting voices from users, though only a few, can serve as indicators for health providers and app developers to jointly improve these apps, which will ultimately facilitate the treatment of prevalent MDs and alleviate the overburdened HC systems worldwide.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>public trust</kwd>
        <kwd>public opinion</kwd>
        <kwd>AI application</kwd>
        <kwd>artificial intelligence</kwd>
        <kwd>mental health care</kwd>
        <kwd>topic modeling</kwd>
        <kwd>topic</kwd>
        <kwd>theme</kwd>
        <kwd>term</kwd>
        <kwd>visualization</kwd>
        <kwd>user feedback</kwd>
        <kwd>user review</kwd>
        <kwd>Google Play</kwd>
        <kwd>health app: mHealth</kwd>
        <kwd>mobile health</kwd>
        <kwd>digital health</kwd>
        <kwd>eHealth</kwd>
        <kwd>mental health</kwd>
        <kwd>mental illness</kwd>
        <kwd>mental disorder</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>“Mental disorders are one of the greatest public health concerns of our time” [<xref ref-type="bibr" rid="ref1">1</xref>]. It is estimated that mental disorders (MDs) account for 32.4% of years lived with disability and 13.0% of disability-adjusted life years [<xref ref-type="bibr" rid="ref2">2</xref>]. MDs have a lifetime prevalence ranging from 12% to 47.4% worldwide [<xref ref-type="bibr" rid="ref3">3</xref>]. They affect millions of people worldwide, imposing a heavy burden on health care (HC) systems [<xref ref-type="bibr" rid="ref4">4</xref>]. The heavy burden of MDs calls for increasing mental health (MH) research worldwide [<xref ref-type="bibr" rid="ref1">1</xref>].</p>
        <p>A possible resolution to this burden is adopting mobile health (mHealth) technologies, especially mobile phone apps [<xref ref-type="bibr" rid="ref4">4</xref>]. Mental health care (MHC) is “having a digital moment” [<xref ref-type="bibr" rid="ref5">5</xref>]. Digital mental health care (DMHC) takes diverse forms, varying from online psychotherapy (eg, cognitive behavioral therapy) to chatbots, which are computer programs using artificial intelligence (AI) and natural language processing to engage in conversations with text or text to speech [<xref ref-type="bibr" rid="ref6">6</xref>]. These AI apps in MHC boast unmatched advantages, including “increased convenience for patients, enhanced adherence to appointments, and access to care that is unbound by geography, backed by evidence that digital mental health care can be effective” [<xref ref-type="bibr" rid="ref5">5</xref>]. Providing evidence-based care, AI health apps have become increasingly popular, evidenced by over 150,000 downloads of an app named PTSD Coach [<xref ref-type="bibr" rid="ref7">7</xref>]. However, if not guided by human therapists, they have high dropout rates [<xref ref-type="bibr" rid="ref8">8</xref>]. By investigating the most popular MH apps downloaded over 100,000 times, Baumel et al [<xref ref-type="bibr" rid="ref9">9</xref>] discovered that 96% of users no longer engaged with the apps after 2 weeks. This is because DMHC may not guarantee “patient privacy, confidentiality, and reliability of service delivery” [<xref ref-type="bibr" rid="ref5">5</xref>]. According to previous studies, what influences the implementation of AI apps includes (1) people-related factors (eg, public attitudes, trust), (2) health system–related factors (eg, clinical responsibility and accountability, the possibility of harm, and issues of regulation and service provision), (3) data-related factors (eg, issues of data security, privacy, consent, and ownership), and (4) tool-related factors (eg, issues of reliability and validity) [<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref12">12</xref>].</p>
        <p>“[The] COVID-19 pandemic has changed health care delivery, including mental health care services around the world” [<xref ref-type="bibr" rid="ref5">5</xref>]. DMHC has been “a welcome and much-needed adoption” in the current pandemic, mainly because no safe alternative can provide MH services. DMHC helps to sustain core MH services. In this state of research, to what extent do users trust AI apps in MHC?</p>
      </sec>
      <sec>
        <title>Trust Defined and Trust in AI Systems (Apps)</title>
        <p>As an important social lubricant for cooperative behavior [<xref ref-type="bibr" rid="ref13">13</xref>], trust has been investigated in various disciplines, which have provided varying definitions, leading to “a multidimensional family of trust concepts,” each with a specific focus [<xref ref-type="bibr" rid="ref13">13</xref>]. Trust is fundamentally “a feeling of certainty that a person or a thing will not fail,” often based on inconclusive evidence and categorized into interpersonal trust, social trust, and trust in automation [<xref ref-type="bibr" rid="ref14">14</xref>]. It is 1 of the means that people can use to reduce complexity in a complex world by decreasing the number of choices to be considered in particular circumstances [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref16">16</xref>]. Since trust can reduce fear, risk, and complexity both online and offline, it is inconceivable that a robust, interactive online environment would be possible without trust [<xref ref-type="bibr" rid="ref13">13</xref>].</p>
        <p>The concept of human trust has been investigated in automated systems [<xref ref-type="bibr" rid="ref17">17</xref>] and online systems [<xref ref-type="bibr" rid="ref13">13</xref>]. Reeves and Nass [<xref ref-type="bibr" rid="ref18">18</xref>] studied how people treated new technologies as humans and as objects of trust, finding that people responded to these technologies almost in the same way that they responded to real people in social relationships by behaving politely or rudely to computer systems; regarding them as assertive, timid, or helpful agents; and responding to them physically. Trust in technology is the belief that a tool, machine, or equipment will not fail [<xref ref-type="bibr" rid="ref19">19</xref>]. “Trusting relationships with the technology have the potential to affect the way the technology is used or not used” [<xref ref-type="bibr" rid="ref16">16</xref>]. The literature on trust in HC systems focused on patient-physician interpersonal trust [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref21">21</xref>] and patients’ trust in HC systems [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref23">23</xref>]. Most research on trust in technology pointed to the trust of the technology operators, for example, the care providers (physicians, nurses, or technicians) in medical settings [<xref ref-type="bibr" rid="ref24">24</xref>]. However, trust in technology needs to be studied from the perspective of users. It is their trust in automated systems that results in appropriate use, disuse, misuse, or even abuse of the automation [<xref ref-type="bibr" rid="ref25">25</xref>].</p>
        <p>Trust in information sources plays an essential part in making the individual well informed of information and willing to act upon it [<xref ref-type="bibr" rid="ref26">26</xref>]. For example, people perceive their risks of COVID-19 infection differently, depending on whether the information is received from social media or from mass media [<xref ref-type="bibr" rid="ref27">27</xref>]. It has been found that messages from privately affiliated media sources can undermine people’s trust in scientific knowledge and health policies [<xref ref-type="bibr" rid="ref28">28</xref>]. Trust is an essential factor that impacts human interactions with AI [<xref ref-type="bibr" rid="ref29">29</xref>]. It is crucial to understand human-AI trust dynamics, especially in the HC domain, in which life may be at risk [<xref ref-type="bibr" rid="ref29">29</xref>]. User perception of AI systems’ capabilities is always a significant factor for trust in them [<xref ref-type="bibr" rid="ref29">29</xref>], and the degree of trust in them considerably influences the level of user reliance on them [<xref ref-type="bibr" rid="ref30">30</xref>] and thus the user efficacy of HC decisions [<xref ref-type="bibr" rid="ref29">29</xref>]. Reliability (ie, AI systems’ predictable and consistent performance of tasks [<xref ref-type="bibr" rid="ref31">31</xref>]) is particularly concerning in HC because AI changes in reliability in the presence of new data [<xref ref-type="bibr" rid="ref32">32</xref>]. The reliability of AI systems is also conditioned both by input data and by user data [<xref ref-type="bibr" rid="ref29">29</xref>]. When trained with insufficient and subjective data from diverse sources, AI systems might generate overfitted or even biased outcomes of which clinical users could not be aware [<xref ref-type="bibr" rid="ref29">29</xref>]. These factors undermine the performance of AI technology [<xref ref-type="bibr" rid="ref33">33</xref>], preventing users from trusting and accepting AI systems [<xref ref-type="bibr" rid="ref29">29</xref>]. Understanding trust in AI systems will shed light on decision-making concerning the acceptance or rejection of technologies, the system designs bringing about positive patient outcomes, and those imposing adverse effects [<xref ref-type="bibr" rid="ref14">14</xref>].</p>
        <p>To the best of our knowledge based on literature search and review, no study has exclusively investigated public trust in AI apps or systems in MHC, although some studies have examined trust in medical technology [<xref ref-type="bibr" rid="ref14">14</xref>]; human trust in AI in HC [<xref ref-type="bibr" rid="ref29">29</xref>]; public trust in COVID-19–related government information sources (eg, the US Centers for Disease Control and Prevention), private sources (eg, FOX and CNN), and social networks (eg, Facebook and Twitter) [<xref ref-type="bibr" rid="ref34">34</xref>]; and public trust in COVID-19–tracing apps [<xref ref-type="bibr" rid="ref35">35</xref>]. In this state of research, there is a pressing need to explore public trust in AI apps or systems in MHC, particularly in the current context where MDs are listed among the greatest public health concerns of our times [<xref ref-type="bibr" rid="ref1">1</xref>].</p>
      </sec>
      <sec>
        <title>Objective</title>
        <p>This study aims to investigate public trust in AI apps in MHC by identifying the major topics (themes) in users’ reviews of the 8 most relevant MH apps with the largest numbers of reviewers.</p>
        <p>Based on this research objective, we proposed the following research questions:</p>
        <list list-type="bullet">
          <list-item>
            <p>Research question 1: Did the users trust the 8 most reviewed MH apps?</p>
          </list-item>
          <list-item>
            <p>Research question 2: What dominant topics (themes) and most relevant terms could be identified in user reviews?</p>
          </list-item>
          <list-item>
            <p>Research question 3: Were the identified dominant topics (themes) concerned with public trust or mistrust?</p>
          </list-item>
          <list-item>
            <p>Research question 4: What implications can the identified trust or mistrust provide for developers and providers of MH apps?</p>
          </list-item>
        </list>
        <p>Topic modeling (TM) was adopted to process the reviews of these apps. As a statistical model, TM arranges unstructured data structurally using latent themes [<xref ref-type="bibr" rid="ref36">36</xref>]. With this model, we scrutinized the reviews of the apps under discussion to reveal the extent to which users trusted these apps. The findings could not only fill the gap in the literature but also facilitate the cooperation between HC practitioners and app developers to design MH intervention programs for these MH apps to respond to public concerns effectively.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Data Collection</title>
        <p>We searched Google Play for the top 20 MH apps with the largest numbers of reviewers, from which we selected the 8 (40%) most relevant apps: (1) <italic>Wysa: Anxiety Therapy Chatbot</italic>; (2) <italic>Youper Therapy</italic>; (3) <italic>MindDoc: Your Companion</italic>; (4) <italic>TalkLife for Anxiety, Depression &#38; Stress</italic>; (5) <italic>7 Cups: Online Therapy for Mental Health &#38; Anxiety</italic>; (6) <italic>BetterHelp-Therapy</italic>; (7) <italic>Sanvello</italic>; and (8) <italic>InnerHour</italic>. Subsequently, we extracted the data of user reviews of these apps posted from January 1, 2020, to April 2, 2022, by using a Python web crawler. After extracting the data, we created a data set of 3931 reviews (reviews of less than 20 words were removed) that consisted of the names of the selected apps, the content of these reviews, the date when these reviews were published, the dominant topic in each review, the contribution of the dominant topic to each review measured in percentage points, and the terms related to each topic. The data set is given in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>. Before the analysis, we followed the standard preprocessing procedures designed in previous studies [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref38">38</xref>] to clean the data using Python 3.0 (Python Software Foundation) and to perform word part-of-speech tagging and text processing using the Python library <italic>spaCy</italic> [<xref ref-type="bibr" rid="ref39">39</xref>,<xref ref-type="bibr" rid="ref40">40</xref>]. Through data cleaning, we converted the words in the reviews into lowercase words; removed stop words, punctuation, numbers, and nonword characters; and stemmed the remaining text [<xref ref-type="bibr" rid="ref41">41</xref>]. To generate more interpretable topics of high quality, we restricted the parts of speech of words to “noun” (NOUN), “verb” (VERB), “adjective” (ADJ), or “proper noun” (PROPN). The standard preprocessing procedures can significantly enhance the performance of algorithms and stabilize the stochastic inference of latent Dirichlet allocation (LDA) [<xref ref-type="bibr" rid="ref38">38</xref>].</p>
      </sec>
      <sec>
        <title>Topic Modeling With LDA</title>
        <p>The statistical methods of unsupervised TM algorithms (which do not need prior labeling or annotations of the documents) were designed to analyze the words (terms) of the original texts to identify the themes (topics) running through a corpus [<xref ref-type="bibr" rid="ref42">42</xref>,<xref ref-type="bibr" rid="ref43">43</xref>]. These algorithms allow users to organize and summarize numerous documents that cannot be annotated manually [<xref ref-type="bibr" rid="ref41">41</xref>], thereby revealing the hidden topics in the documents [<xref ref-type="bibr" rid="ref43">43</xref>]. We adopted the LDA TM technique, which assumes that texts are generated from a mixture of topics [<xref ref-type="bibr" rid="ref44">44</xref>]. LDA is efficient and can generate topics of better quality [<xref ref-type="bibr" rid="ref45">45</xref>]. From the data set created, we generated 2 probability distribution outputs: the probability distribution of topics over documents and the probability distribution of terms over topics [<xref ref-type="bibr" rid="ref41">41</xref>,<xref ref-type="bibr" rid="ref43">43</xref>]. The number of topics was determined by repeating the analysis with different numbers of topics and by comparing the perplexity of each analysis [<xref ref-type="bibr" rid="ref41">41</xref>]. A lower perplexity value indicates a better model fit [<xref ref-type="bibr" rid="ref44">44</xref>], and the perplexity value decreases with the increase in the number of topics [<xref ref-type="bibr" rid="ref41">41</xref>]. Both the simplicity and the interpretability of the textual content need to be considered in choosing the optimal number of topics [<xref ref-type="bibr" rid="ref38">38</xref>].</p>
        <p>We took the coherence score as an assessment metric to evaluate how good a given topic model was and determine the optimal number of topics [<xref ref-type="bibr" rid="ref46">46</xref>] that needed to be extracted from the user reviews. Topic coherence is a qualitative method used to score the coherence of a given topic [<xref ref-type="bibr" rid="ref46">46</xref>]. It measures the semantic similarity between words with high scores in a topic to determine the consistency of a single topic, improving the semantic understanding of the topic [<xref ref-type="bibr" rid="ref36">36</xref>]. We applied the Python package coherence model from <italic>Gensim</italic> to calculate the coherence value [<xref ref-type="bibr" rid="ref47">47</xref>]. As shown in <xref rid="figure1" ref-type="fig">Figure 1</xref>, the coherence score increased to the highest value of 0.45 when the number of topics reached 4, before decreasing gradually, implying that the optimal number of topics was 4. Afterward, we visualized the relationship between these 4 topics and their related terms using Python version 3.6.1 and the <italic>pyLDAvis</italic> tool [<xref ref-type="bibr" rid="ref44">44</xref>].</p>
        <p>When <italic>λ</italic> equals 1, terms are sorted according to their frequency in a topic. Therefore, we set <italic>λ</italic>=1 to visualize the intertopic distance between the 4 topics and the top 30 most relevant terms for each topic, as shown in <xref rid="figure2" ref-type="fig">Figure 2</xref>. We classified these 4 topics into different themes to facilitate better analysis based on the computed topic distance [<xref ref-type="bibr" rid="ref44">44</xref>]. In the 2D plane (<xref rid="figure2" ref-type="fig">Figure 2</xref>), the 4 topics are shown in the form of 4 circles. The size of each circle represents the overall prevalence of the topic, the overlap between circles 3 and 4 means the overlap between topics 3 and 4, and the distance between the circle centers stands for topic distance [<xref ref-type="bibr" rid="ref44">44</xref>]. The content of each topic was generated according to its corresponding set of keywords (terms) [<xref ref-type="bibr" rid="ref48">48</xref>]. Considering that the output of statistical measures cannot be guaranteed to be interpretable due to the language complexity [<xref ref-type="bibr" rid="ref49">49</xref>], we complemented automatic text statistics with manual interpretation when analyzing the topics. The topics were named based on the associated keywords to illustrate those topics [<xref ref-type="bibr" rid="ref48">48</xref>].</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>Coherence score for the topic numbers.</p>
          </caption>
          <graphic xlink:href="humanfactors_v9i4e38799_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <fig id="figure2" position="float">
          <label>Figure 2</label>
          <caption>
            <p>Intertopic distance map and top 30 most relevant terms for topic 4. Refer to the interactive web-based visualization in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref> for other topics. PC: principal component.</p>
          </caption>
          <graphic xlink:href="humanfactors_v9i4e38799_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Ethical Considerations</title>
        <p>All reviewers anonymized themselves when posting app reviews online. We just downloaded the anonymized data from the apps. Therefore, an ethical review was not necessary for this paper.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Review Distribution Over Apps and Time</title>
        <p><xref rid="figure3" ref-type="fig">Figure 3</xref> shows the distribution of reviews over the 8 selected apps. Over the period from January 1, 2020, to April 2, 2022, the largest number of reviews were posted on <italic>InnerHour</italic> (n=663, 16.9%), followed by <italic>Wysa: Anxiety Therapy Chatbot</italic> (n=559, 14.2%), <italic>MindDoc: Your Companion</italic> (n=538, 13.7%), and <italic>7 Cups: Online Therapy for Mental Health &#38; Anxiety</italic> (n=554, 14.1%). Less than 450 reviews were published on <italic>Youper Therapy</italic> (n=431, 11%) and <italic>BetterHelp-Therapy</italic> (n=468, 11.9%). Far fewer than 400 reviews were released on <italic>TalkLife for Anxiety</italic> (n=356, 8.8%) and <italic>Sanvello</italic> (n=362, 9.2%). The different numbers of reviews somehow reflected the varying popularity of these 8 apps over the period under discussion. <xref rid="figure4" ref-type="fig">Figure 4</xref> displays the number of reviews published over time, which peaked and waned on different dates. Although it is difficult to attribute the 2 peaks in 2021 to specific factors, it is likely that the peaking period in the middle of 2020 possibly reflected the increased need for MHC apps during the global outbreak of the COVID-19 pandemic, as evidenced by the following reviews:</p>
        <disp-quote>
          <p>It’s really helpful specially during this pandemic. You can find very calm listeners who will be patient and understanding while listening.</p>
        </disp-quote>
        <disp-quote>
          <p>Love this app. Tried it because of a friend’s recommendation and best decision in this challenging time of a pandemic. Really cleared my mind and helped me regain control and life perspective. Will make it a daily habit.</p>
        </disp-quote>
        <disp-quote>
          <p>This app is perfect for these times. With anxiety issues predating the pandemic, I'll probably continue using it after the world gets back on track. Thank you!</p>
        </disp-quote>
        <fig id="figure3" position="float">
          <label>Figure 3</label>
          <caption>
            <p>Number of reviews by app.</p>
          </caption>
          <graphic xlink:href="humanfactors_v9i4e38799_fig3.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <fig id="figure4" position="float">
          <label>Figure 4</label>
          <caption>
            <p>Number of reviews over time.</p>
          </caption>
          <graphic xlink:href="humanfactors_v9i4e38799_fig4.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Topic Prevalence</title>
        <p>By applying LDA TM, we classified into 4 topics the collected data of user reviews of the 8 selected AI apps in MHC published from January 1, 2020, to April 2, 2022 (<xref ref-type="table" rid="table1">Table 1</xref>). Topic 4 (<italic>cheering people up</italic>) was the most popular and dominant topic, occurring in 27.2% (n=1069) of the 3931 reviews collected, closely followed by topic 3 (<italic>calming people down</italic>), which appeared in 26.2% (n=1029) of the 3931 reviews. Topic 2 (<italic>helping figure out the inner world</italic>) ranked as the third-most popular and dominant topic, showing up in 24.5% (n=963) of the 3931 reviews. Topic 1 (<italic>being an alternative or complement to a therapist</italic>) accounted for 22.1% (n=870) of the 3931 reviews. The similar areas of the 4 circles representing these 4 topics in <xref rid="figure2" ref-type="fig">Figure 2</xref> indicate the similar overall prevalence of these topics in the collected reviews.</p>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Topic classification and keywords.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="270"/>
            <col width="0"/>
            <col width="500"/>
            <col width="200"/>
            <thead>
              <tr valign="top">
                <td colspan="3">Theme and classification</td>
                <td>Keywords</td>
                <td>Reviews (N=3931), n (%)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="5">
                  <bold>Theme 1: being an alternative or complement to a therapist</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Topic 1: being an alternative or complement to a therapist</td>
                <td colspan="2">great, therapist, time, work, therapy, issue, chat, counselor, easy, option, week, person, experience, money, support, month, session, message, year, service, start, worth, account, enjoy, video, conversation, update, access, call, log</td>
                <td>870 (22.1)</td>
              </tr>
              <tr valign="top">
                <td colspan="5">
                  <bold>Theme 2: helping figure out the inner world</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Topic 2: helping figure out the inner world</td>
                <td colspan="2">helpful, day, give, find, good, app, mood, time, question, feeling, mental_health, track, thought, change, emotion, answer, phone, notification, check, add, daily, tool, positive, community, hard, journal, provide, insight, negative, advice</td>
                <td>963 (24.5)</td>
              </tr>
              <tr valign="top">
                <td colspan="5">
                  <bold>Theme 3: dispelling negative emotions</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Topic 3: calming people down</td>
                <td colspan="2">app, love, thing, pay, lot, free, anxiety, recommend, depression, premium, feature, understand, stress, calm, AI<sup>a</sup>, version, hope, struggle, care, exercise, meditation, sleep, afford, activity, improve, good, offer, a lot, awesome, deal</td>
                <td>1029 (26.2)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Topic 4: cheering people up</td>
                <td colspan="2">app, feel, make, people, talk, good, amazing, problem, listener, life, nice, bad, Wysa, friend, download, star, listen, happy, real, review, open, post, place, bit, put, share, cup, start, fix, part</td>
                <td>1069 (27.2)</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>AI: artificial intelligence.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Intertopic Distance</title>
        <p><xref rid="figure2" ref-type="fig">Figure 2</xref> provides an overview of the topic model we constructed. The 4 circles in this figure represent the 4 topics dominating the 3931 reviews. The intertopic distances characterized by multidimensional scaling on the 2D plane in <xref rid="figure2" ref-type="fig">Figure 2</xref> imply the semantic similarity between these 4 topics: topics 3 and 4 overlap and are thus semantically similar; these 2 topics are semantically distant from topics 1 and 2, which are also semantically distant from each other.</p>
      </sec>
      <sec>
        <title>Topic Terms and Content</title>
        <p><xref rid="figure2" ref-type="fig">Figure 2</xref> also shows the top 30 most relevant terms for topic 4, representing 24.8% of the tokens. As this topic constitutes the highest proportion (n=1069, 27.2%) of the collected reviews, it is presented as a typical illustration. Since the blue bar and the red bar represent the overall term frequency and the estimated term frequency within the selected topic, respectively, the topic content can be better interpreted based on this approach [<xref ref-type="bibr" rid="ref50">50</xref>,<xref ref-type="bibr" rid="ref51">51</xref>]. With regard to topic 4, users of the 8 selected AI apps in MHC preferred to use words indicating the apps’ function of cheering people up, such as <italic>make</italic>, <italic>feel</italic>, <italic>happy</italic>, <italic>good</italic>, <italic>amazing</italic>, <italic>listener</italic>, <italic>friend</italic>, and <italic>nice</italic>. In this way, we could study the content of this topic and name it. The word clouds of the 4 dominant topics in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref> complement <xref rid="figure2" ref-type="fig">Figure 2</xref> in demonstrating the term frequency of the top 30 most relevant terms of each topic and implying the content of each topic.</p>
      </sec>
      <sec>
        <title>Topic Classification and Keywords</title>
        <p>Drawing on TM to analyze the user reviews and compare the perplexity indices, we discovered that it was optimal to classify the 4 dominant topics covered in the reviews into 3 themes, as shown in <xref ref-type="table" rid="table1">Table 1</xref>. The illustrative quotes for these themes are displayed in <xref ref-type="boxed-text" rid="box1">Textbox 1</xref>.</p>
        <p>Topic 1 (theme 1, “being an alternative or complement to a therapist”) deals with reviews that describe the apps’ function as an alternative or even a complement to a human MH provider (eg, nurse, doctor, physician, psychiatrist) when such a human therapist is unavailable due to the limitation of working time, space, budget, and social conditions (eg, the repeated resurgences of COVID-19); when app users attach great importance to privacy and social stigma related to MH problems; or when DMHC takes prevalence or will be institutionalized in the MHC domain. Topic 2 (theme 2, “helping figure out the inner world”) focuses on the apps’ role in helping users track their psychic world to gain a better understanding of their feelings and emotions. By expressing every emotional state to the apps, users can keep themselves in control emotionally, turning out to be a better, sounder self mentally. Topics 3 and 4 (theme 3, “dispelling negative emotions”) point to the emotion-soothing purpose of the apps under discussion. Specifically, these apps can serve to mitigate stress, anxiety, and depression that haunt users, effectively calming them down and cheering them up by behaving as a bosom friend, a good listener, and a constructive adviser, while avoiding judging them by what they say during their venting of various types of feelings.</p>
        <boxed-text id="box1" position="float">
          <title>Illustrative quote(s) of each theme.</title>
          <p>
            <bold>Theme 1</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>“Great! Very calming and I haven’t been able to see my therapist in a while and this really helped. Great quality too.”</p>
            </list-item>
          </list>
          <p>
            <bold>Theme 2</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>“This app has helped me a lot on my mental health. I feel much more in tune with myself and my emotions and all because this app helped me figure out myself and my inner world better. Plus I also have someone I can express everything at the end of the day.”</p>
            </list-item>
          </list>
          <p>
            <bold>Theme 3</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>“It’s a great help. It calms me down some and it’s calming to know that I wouldn’t be judged by what I say.”</p>
            </list-item>
            <list-item>
              <p>“Thanks to the Wysa team for making this! It’s been making it much easier for me to manage my stress (:”</p>
            </list-item>
          </list>
        </boxed-text>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>MDs represent a tremendous public health concern of our times [<xref ref-type="bibr" rid="ref1">1</xref>], which is increasingly overburdening the HC systems worldwide. This is especially true during the COVID-19 pandemic, which has caused many MDs worldwide [<xref ref-type="bibr" rid="ref52">52</xref>]. In this context, Web 2.0–empowered DMHC apps are an optimal solution because there is currently a “tectonic shift in the ways in which patients consume health and medical information” [<xref ref-type="bibr" rid="ref53">53</xref>]. Digital health interventions have proved effective in mitigating negative health habits and outcomes, leveraging patients’ growing proactivity in obtaining health information online [<xref ref-type="bibr" rid="ref54">54</xref>]. This study is the first investigation of public trust in AI apps in MHC from the perspective of user reviews of MHC apps. Applying TM, we managed to manipulate unstructured user reviews, discovering 4 dominant topics hidden in a data set of 3931 reviews and categorizing these topics into 3 themes based on topic coherence and intertopic distance (semantic similarity).</p>
        <p>The top 30 most relevant terms for the 4 dominant topics (<xref rid="figure2" ref-type="fig">Figures 2</xref> and <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>) indicate that users of the 8 selected apps generally trust these apps, having a positive experience with these apps and feeling satisfied with them. Specifically, this was evidenced by the top terms <italic>great</italic>, <italic>therapist</italic>, <italic>work</italic>, <italic>chat</italic>, <italic>counselor</italic>, <italic>easy</italic>, and <italic>option</italic> in topic 1; <italic>helpful</italic>, <italic>find</italic>, <italic>give</italic>, <italic>mood</italic>, <italic>good</italic>, <italic>question</italic>, <italic>positive</italic>, and <italic>feeling</italic> in topic 2; <italic>app</italic>, <italic>love</italic>, <italic>free</italic>, <italic>pay</italic>, <italic>lot</italic>, <italic>recommend</italic>, <italic>anxiety</italic>, <italic>depression</italic>, and <italic>stress</italic> in topic 3; and <italic>app</italic>, <italic>make</italic>, <italic>feel</italic>, <italic>people</italic>, <italic>talk</italic>, <italic>good</italic>, <italic>life</italic>, <italic>amazing</italic>, <italic>listener</italic>, <italic>nice</italic>, <italic>friend</italic>, <italic>open</italic>, and <italic>happy</italic> in topic 4. In medical settings, trust results in enhanced health self-efficacy, increased treatment adherence, and more positive health outcomes [<xref ref-type="bibr" rid="ref55">55</xref>,<xref ref-type="bibr" rid="ref56">56</xref>]. This result confirms a previous research finding that overall user trust in conversational agents (CAs) is increasing [<xref ref-type="bibr" rid="ref57">57</xref>].</p>
        <p>The 4 topics that the users focused on were classified into 3 themes based on LDA TM. Theme 3 (<italic>dispelling negative emotions</italic>) covered topics 3 (<italic>calming people down</italic>) and 4 (<italic>cheering people up</italic>), which together dominated more than half (n=2098, 53.4%) of the reviews (N=3931) under scrutiny. This theme highlighted the apps’ perceived function of helping people out of depression, anxiety, and stress. The results revealed that the users are mainly concerned with positive MH outcomes when adopting AI apps for MH interventions. They sought social support messages concerning MH on MHC apps mainly because they trusted the apps in terms of (1) the look of the technology, (2) perceived reliability, (3) accuracy, (4) consistency, and (5) feedback from the technology [<xref ref-type="bibr" rid="ref14">14</xref>], as demonstrated by the following reviews:</p>
        <disp-quote>
          <p>The app is also easy to navigate and seems solid (no tech issues). Also, nice professional appearance.</p>
        </disp-quote>
        <disp-quote>
          <p>Very cute and user-friendly layout. Takes you step by step to teach you by example how to take the reins on your own thoughts and emotions. Awesome app!</p>
        </disp-quote>
        <disp-quote>
          <p>Reliable. It’s a really great app, the listeners out on the platform are professional and patient. I have personally benefited from this app and I can't stress this enough, it is a really good app. If you just need an ear to listen to you, without any judgments whatsoever, try it.</p>
        </disp-quote>
        <disp-quote>
          <p>It’s scary how meticulously accurate this personality test is. It is like having a paid friend Psychologist on hand during these uncertain times of total lockdown...</p>
        </disp-quote>
        <disp-quote>
          <p>7 cups has consistently and diligently kept the essence of being there for anyone anywhere anytime, very alive and accessible</p>
        </disp-quote>
        <disp-quote>
          <p>I love being able to message my counselor whenever I need to, it helps with needing to vent and get positive, constructive feedback quickly, on everyday stressors that feel overwhelming.</p>
        </disp-quote>
        <p>These quoted reviews show that some reviewers tend to trust computer systems more than other humans (ie, human MHC providers) because automation is expected to be relatively perfect [<xref ref-type="bibr" rid="ref58">58</xref>], in terms of appearance, reliability, accuracy, consistence, and targeted feedback [<xref ref-type="bibr" rid="ref14">14</xref>].</p>
        <p>Moreover, our results confirmed that <italic>helping figure out the inner world</italic> (theme 2) was another important factor determining public trust. Reviewers repeatedly mentioned <italic>thought tracking</italic>, <italic>best mood tracker</italic>, <italic>journalizing my thoughts and feelings</italic>, <italic>making me take a proper look at my thoughts and feelings</italic>, <italic>writing down my thoughts and then framing them to be more positive</italic>, etc. The function of enabling users to follow through with their MH made them trust their MH with these apps due to the negative social perception of MDs [<xref ref-type="bibr" rid="ref59">59</xref>], which prevents people from seeking professional help proactively [<xref ref-type="bibr" rid="ref60">60</xref>]. This result aligns with previous studies [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref59">59</xref>] that mHealth technologies (eg, MH apps) can protect users’ privacy and reduce the influence of the social stigma attached to MDs. Users commented that “it can be nice to vent to something that isn’t someone who would judge you.” In addition, people are most likely to depend on the advice and support provided by professional apps when developing appropriate responses to MH problems [<xref ref-type="bibr" rid="ref54">54</xref>]. The professional interventions in thought tracking supplied by the selected apps were another essential contributor to the high degree of public trust in these apps, as evidenced by some reviews, such as:</p>
        <disp-quote>
          <p>The bot navigates you through series of practical and professional activities</p>
        </disp-quote>
        <disp-quote>
          <p>Very professional</p>
        </disp-quote>
        <disp-quote>
          <p>Professional help</p>
        </disp-quote>
        <disp-quote>
          <p>Helps me assemble my thoughts by asking me relevant questions</p>
        </disp-quote>
        <p>Additionally, our research results suggest that MH app users also reflect on the role of MH apps as an alternative or a supplement to human therapists (theme 1). This implies that app users attach great importance to digital health interventions, while still trusting human MHC providers. Although some users accepted MH apps as an alternative to human therapists, for example,</p>
        <disp-quote>
          <p>This app is my perfect personal therapist,</p>
        </disp-quote>
        <p>most users took them as a complement to human therapists, for example,</p>
        <disp-quote>
          <p>Very helpful between therapy appointments and during times when I wasn’t seeing a therapist.</p>
        </disp-quote>
        <p>The tectonic change in patients’ consuming health and medical information [<xref ref-type="bibr" rid="ref53">53</xref>] significantly shifted the landscape for interventions seeking to change health behavior, each with its associated benefits and risks [<xref ref-type="bibr" rid="ref61">61</xref>]. “Although exposure to these products is becoming ubiquitous, electronic health information is novel, incompletely disseminated, and frequently inaccurate, which decreases public trust” [<xref ref-type="bibr" rid="ref54">54</xref>]. That is why a few users mistrusted the selected AI apps in their reviews:</p>
        <disp-quote>
          <p>It’s the same vague questions every time with no room for explanation. Very inaccurate</p>
        </disp-quote>
        <disp-quote>
          <p>But the therapists seem very disconnected and don't really seem to care much at all, responding in broken or incomplete sentences</p>
        </disp-quote>
        <p>However, AI apps in MHC are gaining increasing popularity due to their unmatched advantages [<xref ref-type="bibr" rid="ref5">5</xref>], the provision of evidence-based care [<xref ref-type="bibr" rid="ref7">7</xref>], and the change in HC delivery due to the COVID-19 pandemic [<xref ref-type="bibr" rid="ref5">5</xref>]. As a result, AI apps in MHC have become “a welcome and much-needed adoption” [<xref ref-type="bibr" rid="ref5">5</xref>].</p>
        <p>Admittedly, there were some dissenting voices in the collected reviews. These disagreements reflected some aspects of the selected apps that undermined public trust, including:</p>
        <list list-type="bullet">
          <list-item>
            <p>Interface design</p>
          </list-item>
        </list>
        <disp-quote>
          <p>The interface sucks</p>
        </disp-quote>
        <list list-type="bullet">
          <list-item>
            <p>Charges</p>
          </list-item>
        </list>
        <disp-quote>
          <p>It was an exorbitant in-app purchase</p>
        </disp-quote>
        <list list-type="bullet">
          <list-item>
            <p>Engagement</p>
          </list-item>
        </list>
        <disp-quote>
          <p>...chat it was not engaged at all</p>
        </disp-quote>
        <list list-type="bullet">
          <list-item>
            <p>Reliability</p>
          </list-item>
        </list>
        <disp-quote>
          <p>Broken app. Chats are so unstable I couldn't get more than 2 messages before there was an error. The interface is broken, half of the stuff barely works and everything lags. The idea behind it is amazing but in practice it unfortunately doesn’t work at all.</p>
        </disp-quote>
        <list list-type="bullet">
          <list-item>
            <p>Ease of use</p>
          </list-item>
        </list>
        <disp-quote>
          <p>The app itself isn’t as easy to navigate compared to the desktop site</p>
        </disp-quote>
        <p>These negative comments of reviewers indicate that the reliability of service [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref31">31</xref>], AI systems’ capabilities [<xref ref-type="bibr" rid="ref29">29</xref>], people-related factors (eg, public attitudes, trust), health system–related factors (eg, issues of regulation and service provision), and tool-related factors (eg, issues of reliability) [<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref12">12</xref>] all potentially reduce public trust in DMHC delivered through AI apps or systems. Among these factors damaging public trust, reliability or predictable and consistent performance arouses particular concern in HC [<xref ref-type="bibr" rid="ref32">32</xref>]. These findings are consistent with those reported in previous studies [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>].</p>
        <p>All these aspects need to be improved to enhance public trust. The technology design and the integration of technology into effectively performing systems are most likely to be associated with patient trust, which impacts patient outcomes (eg, patient satisfaction and adherence to medical advice and treatment) [<xref ref-type="bibr" rid="ref62">62</xref>].</p>
        <p>Overall, the investigation of user reviews based on the TM approach can shed light on public trust in AI apps in MHC. “Understanding trust in medical technologies will provide insight into decision making about which technologies will be accepted or rejected, which work system designs will lead to positive patient outcomes, and which will have the inverse effect” [<xref ref-type="bibr" rid="ref14">14</xref>].</p>
      </sec>
      <sec>
        <title>Implications</title>
        <p>Trust is an emotional construct that features patients’ comfortable feeling of faith in or dependence on care providers’ intentions, with common dimensions, including “competence, compassion, privacy and confidentiality, reliability and dependability, and communication” [<xref ref-type="bibr" rid="ref63">63</xref>]. In the current and future context of technology replacing human elements in medical practices [<xref ref-type="bibr" rid="ref14">14</xref>] and HC providers depending more on AI [<xref ref-type="bibr" rid="ref29">29</xref>], a proper trust relationship [<xref ref-type="bibr" rid="ref29">29</xref>] or calibrated trust [<xref ref-type="bibr" rid="ref64">64</xref>] needs to be established between users and AI for HC for effective medical and health decisions [<xref ref-type="bibr" rid="ref29">29</xref>]. To this end, important issues relevant to trust in AI for HC apps should be studied, including essential factors impacting trust in AI for HC, potential ways to improve trust relationships, and their influence on trust [<xref ref-type="bibr" rid="ref29">29</xref>].</p>
        <p>Currently, the adoption of AI systems in the HC domain is considerably hindered by a lack of trust in this technology [<xref ref-type="bibr" rid="ref29">29</xref>]. Trust in AI is conditioned both by human factors and by properties of AI systems. Human factors include users’ education, experiences, personal biases, and perception of automation [<xref ref-type="bibr" rid="ref29">29</xref>]. Properties of AI systems involve the look of the technology, perceived reliability, accuracy, consistency, and feedback from the technology [<xref ref-type="bibr" rid="ref14">14</xref>]. Considering these contributors to public trust in AI systems, we propose that patients be provided with education and information about the technology and its use [<xref ref-type="bibr" rid="ref14">14</xref>] and that developers of AI apps for HC well consider health system–related factors, data-related factors, and tool-related factors [<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref12">12</xref>] when designing HC apps and systems. In addition, mechanisms need to be incorporated into the development of AI to build and keep an appropriately balanced, optimal level of user trust matching the capacities of AI systems [<xref ref-type="bibr" rid="ref30">30</xref>].</p>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>This study may have some limitations. Most importantly, user reviews of the selected apps were subjective user comments based on the individual experience with the apps. Public trust in AI apps in MHC reflected by such self-reported data may be influenced by various factors, such as prior experience with the source, sociodemographic background, or health behaviors [<xref ref-type="bibr" rid="ref54">54</xref>]. Thus, the user reviews may be biased, possibly influencing our research findings to some extent. Second, the user experience and satisfaction with AI apps in MHC are likely to be impacted by the current social situations. Therefore, public trust in such apps may vary according to changing social conditions, such as the current resurgences of the COVID-19 pandemic. Such changing status of public trust may thus not necessarily be triggered by the improved or deteriorating performance of the AI apps in MHC. The overall high degree of public trust found in this study may attenuate when the pandemic ends. Future studies need to consider the dynamics of the review data. Third, this study only retrieved reviews posted from January 1, 2020, to April 2, 2022. Further studies may expand this period to test the generalizability of our findings. Fourth, future research needs to consider more apps to verify the generalizability of the results of this study.</p>
      </sec>
      <sec>
        <title>Conclusion</title>
        <p>This is the first study investigating the public trust in AI apps in MHC from the perspective of user reviews using the TM technique. The automatic text analysis and complementary manual interpretation of the collected reviews allowed us to discover 4 dominant topics hidden in a data set of 3931 unstructured reviews and categorize these topics into 3 groups of themes based on topic coherence and intertopic distance (semantic similarity). From these topics and themes, we managed to study the status of public trust in AI apps in MHC, finding an overall high degree of public trust. Although shaped by various factors, public trust in technology can broadly reflect the performance of the technology itself. The negative voices from users can serve as indicators for health providers and app developers to jointly improve these apps, which will ultimately facilitate the treatment of prevalent MDs and alleviate the overburdened HC systems worldwide. More research needs to be conducted into the design of AI apps for health counseling that ensures the validity of any provided recommendations and interventions. Meanwhile, patients must be reminded that health recommendations from any nonauthoritative sources need to be confirmed with HC professionals before they are acted on [<xref ref-type="bibr" rid="ref65">65</xref>].</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>App review data and topic modeling results.</p>
        <media xlink:href="humanfactors_v9i4e38799_app1.xlsx" xlink:title="XLSX File  (Microsoft Excel File), 541 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>Topic Modeling word clouds of the 4 dominant topics.</p>
        <media xlink:href="humanfactors_v9i4e38799_app2.png" xlink:title="PNG File , 258 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">AI</term>
          <def>
            <p>artificial intelligence</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">DMHC</term>
          <def>
            <p>digital mental health care</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">HC</term>
          <def>
            <p>health care</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">LDA</term>
          <def>
            <p>latent Dirichlet allocation</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">MD</term>
          <def>
            <p>mental disorder</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">MH</term>
          <def>
            <p>mental health</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">MHC</term>
          <def>
            <p>mental health care</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb8">mHealth</term>
          <def>
            <p>mobile health</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb9">TM</term>
          <def>
            <p>topic modeling</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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