<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="research-article"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Hum Factors</journal-id><journal-id journal-id-type="publisher-id">humanfactors</journal-id><journal-id journal-id-type="index">6</journal-id><journal-title>JMIR Human Factors</journal-title><abbrev-journal-title>JMIR Hum Factors</abbrev-journal-title><issn pub-type="epub">2292-9495</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v12i1e65745</article-id><article-id pub-id-type="doi">10.2196/65745</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Paper</subject></subj-group></article-categories><title-group><article-title>Using Social Media Platforms to Raise Health Awareness and Increase Health Education in Pakistan: Structural Equation Modeling Analysis and Questionnaire Study</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Munir</surname><given-names>Malik Mamoon</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Ahmed</surname><given-names>Nabil</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution>Integral Global Consulting LLC</institution><addr-line>3541 Habersham at Northlake Parkway Road, Building E</addr-line><addr-line>Tucker</addr-line><addr-line>GA</addr-line><country>United States</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Kushniruk</surname><given-names>Andre</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Bilal</surname><given-names>Atif</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Khairulbahri</surname><given-names>Muhamad</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Javed</surname><given-names>Muhammed</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Malik Mamoon Munir, PhD, Integral Global Consulting LLC, 3541 Habersham at Northlake Parkway Road, Building E, Tucker, GA, 30084, United States, 1 678-427-0014; <email>mamoon@integralglobal.net</email></corresp></author-notes><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>7</day><month>4</month><year>2025</year></pub-date><volume>12</volume><elocation-id>e65745</elocation-id><history><date date-type="received"><day>24</day><month>08</month><year>2024</year></date><date date-type="rev-recd"><day>09</day><month>02</month><year>2025</year></date><date date-type="accepted"><day>10</day><month>02</month><year>2025</year></date></history><copyright-statement>&#x00A9; Malik Mamoon Munir, Nabil Ahmed. Originally published in JMIR Human Factors (<ext-link ext-link-type="uri" xlink:href="https://humanfactors.jmir.org">https://humanfactors.jmir.org</ext-link>), 7.4.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Human Factors, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://humanfactors.jmir.org">https://humanfactors.jmir.org</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://humanfactors.jmir.org/2025/1/e65745"/><abstract><sec><title>Background</title><p>Current health care education methods in Pakistan use traditional media (eg, television and radio), community health workers, and printed materials, which often fall short of reach and engagement among most of the population. The health care sector in Pakistan has not yet used social media effectively to raise awareness and provide education about diseases. Research on the impact social media can have on health care education in Pakistan may expand current efforts, engage a wider audience, and reduce the disease burden on health care facilities.</p></sec><sec><title>Objective</title><p>This study aims to evaluate the perceptions of health care professionals and paramedic staff regarding social media use to raise awareness and educate people about diseases as a potential means of reducing the disease burden in Pakistan.</p></sec><sec sec-type="methods"><title>Methods</title><p>The study used two-stage structural equation modeling (SEM). Data analysis used AMOS 26.0 software, adopting scales from previous literature. Four-item scales for each social media usefulness and health awareness construct and 8-item scales for health care education constructs were adopted on the basis of their higher loading in alignment with psychometric literature. A 7-point Likert scale was used to measure each item. Data collection used convenience sampling, with questionnaires distributed to more than 450 health care professionals and paramedic staff from 2 private hospitals in Lahore, Pakistan. There were 389 useful responses received. However, 340 completed questionnaires were included in the data analysis.</p></sec><sec sec-type="results"><title>Results</title><p>The study found that all the squared multiple correlation (SMC) values were greater than 0.30. Furthermore, convergent validity was measured using (1) standardized factor loading (found greater than 0.5), (2) average variance explained (found greater than 0.5), and (3) composite reliability (found greater than 0.7). The confirmatory factor analysis (CFA) of the measurement model indicated the fitness of the constructs (Chi-square minimum [CMIN]=357.62; CMIN/degrees of freedom [DF]=1.80; Goodness of Fit [GFI]=0.90; Adjusted Goodness of Fit Index [AGFI]=0.89; Buntler-Bonett Normed Fit Index [NFI]=0:915; Comparative Fit Index [CFI]=0:93; Root Mean Square Residual [RMR]=0:075; Root Mean Square Error of Approximation [RMSEA]=0:055). Moreover, the structural model fitness was also confirmed (CMIN=488.6; CMIN/DF=1.85; GFI=0.861; AGFI=0.893; NFI=0.987; CFI=0.945; RMR=0:079; RMSEA=0.053). Hence, the results indicated that social media usefulness has a positive and significant effect on health awareness (hypothesis 1: <italic>&#x03B2;</italic>=.669, <italic>P</italic>&#x003C;.001), and health awareness has a positive and significant effect on health care education in Pakistan (hypothesis 2: <italic>&#x03B2;</italic>=.557, <italic>P</italic>&#x003C;.001).</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>This study concludes that health care professionals and paramedic staff in private hospitals support the use of social media to raise awareness and provide health care education. It is considered an effective tool for reducing the disease burden in Pakistan. The study results also revealed that young health care professionals are more inclined toward social media usage and express the need for legislation to support it and establish a monitoring process to avoid misinformation.</p></sec></abstract><kwd-group><kwd>social media</kwd><kwd>health awareness</kwd><kwd>health education</kwd><kwd>innovation diffusion theory</kwd><kwd>structural equation modeling</kwd><kwd>disease burden</kwd><kwd>healthcare facilities</kwd><kwd>health professionals</kwd><kwd>misinformation</kwd><kwd>cost effective</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><sec id="s1-1"><title>Background</title><p>In Pakistan, the health care system is resource-strapped, leading to challenges in preventing infectious diseases. The country has a high maternal mortality rate (186 deaths per 100,000 live births) and a high infant mortality rate (56 deaths per 1000 live births) [<xref ref-type="bibr" rid="ref1">1</xref>]. Many complications arise from a lack of awareness and education about prenatal care, safe delivery practices, and postnatal care [<xref ref-type="bibr" rid="ref2">2</xref>]. Moreover, poor understanding of nutrition has led to widespread malnutrition among children and pregnant women in Pakistan [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref2">2</xref>]. Malnutrition in children leads to stunted growth, weakened immunity, and impaired cognitive development [<xref ref-type="bibr" rid="ref2">2</xref>]. The prevalence of stunting in Pakistan is among the highest in the world, affecting approximately 38% of children under 5 years of age [<xref ref-type="bibr" rid="ref3">3</xref>].</p><p>In this context, health awareness and education campaigns potentially lead to behavioral changes and alleviate the burden on health facilities [<xref ref-type="bibr" rid="ref4">4</xref>]. Public health campaigns, particularly those focused on preventive measures like vaccination, hygiene, and lifestyle changes, have substantially reduced the incidence of various diseases [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref5">5</xref>]. For example, handwashing campaigns alone have reduced respiratory infections by up to 23% [<xref ref-type="bibr" rid="ref6">6</xref>]. Awareness campaigns aimed at managing chronic conditions, such as diabetes and hypertension, through education on medication adherence and lifestyle modifications have reduced complications and hospital visits [<xref ref-type="bibr" rid="ref7">7</xref>]. These interventions have been shown to improve health outcomes and reduce health care costs by up to 25% [<xref ref-type="bibr" rid="ref8">8</xref>].</p><p>Among various tools and health interventions, social media has attained the most global attention to enhance health awareness and education to a wider population and discovered its significant impact in addressing health care issues [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref10">10</xref>]. According to social media statistics, social media users worldwide reached 5.04 billion in January 2024, representing 63% of the world&#x2019;s population, with users growing 6% annually [<xref ref-type="bibr" rid="ref11">11</xref>]. On average, social media users spend 2 hours and 23 minutes daily on social media platforms and see various content [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref12">12</xref>]. Social media tools, such as Facebook (Meta), TikTok (ByteDance), Twitter (subsequently rebranded as X), Instagram (Meta), and YouTube (Google), facilitate health care professionals in educating and influencing perceptions, including networking, sharing ideas, disseminating information, demonstrating, coaching, consulting, and advertising [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref13">13</xref>]. Existing literature in the health care sector has exhibited the transformative potential of social media and its usefulness in spreading health awareness and education [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref13">13</xref>].</p><p>However, the existing literature lacks comprehensive insights into the role of social media in fostering health awareness and education within developing countries, particularly Pakistan. This study addresses this gap by applying Innovation Diffusion Theory to examine the mediating effect of health awareness and empirically testing the impact of social media on health care education among health care professionals.</p><p>Therefore, the primary objective of this study is to investigate the role of social media in enhancing health awareness and its subsequent impact on health care education in Pakistan. By addressing the gap in the literature concerning the adoption of social media for health care communication in developing countries, this research aims to provide empirical evidence and practical insights for leveraging digital platforms to improve health outcomes.</p><p>This section comprehensively reviews existing literature on social media usefulness, health awareness, health care education, and health care sector challenges in Pakistan.</p></sec><sec id="s1-2"><title>Social Media Usefulness</title><p>The global adoption of social media platforms has led to scalable public health interventions, increased precision and effectiveness, and improved resource mobilization [<xref ref-type="bibr" rid="ref14">14</xref>]. Social media has encouraged healthy behaviors and enabled informed choices through sharing tips, challenges, and success stories [<xref ref-type="bibr" rid="ref9">9</xref>]. Health care professionals can provide accurate, evidence-based information as trusted sources [<xref ref-type="bibr" rid="ref11">11</xref>]. Their involvement is vital due to their expertise, credibility, and ability to reach a wide audience. Campaigns through social media on vaccination, hygiene practices, mental health awareness, and other preventive measures have been helpful in countries like Germany and France [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref10">10</xref>].</p><p>Moreover, social media has been effectively used to combat the pandemic and other diseases during the COVID-19 pandemic [<xref ref-type="bibr" rid="ref15">15</xref>]. The social media data were instrumental in tracking the spread of the COVID-19 virus and disseminating accurate information [<xref ref-type="bibr" rid="ref16">16</xref>]. Campaigns on platforms such as Facebook and Twitter have been used to promote vaccination, leading to increased uptake in various regions [<xref ref-type="bibr" rid="ref12">12</xref>]. Tailored messaging on HIV prevention for at-risk populations has shown to be more effective than generalized campaigns [<xref ref-type="bibr" rid="ref13">13</xref>]. Moreover, existing literature has shown examples of successful public health campaigns, such as:</p><list list-type="order"><list-item><p>#SmearForSmear Campaign: this social media campaign aimed to raise awareness about cervical cancer screening and successfully increase screening rates by leveraging the reach of platforms such as Twitter and Instagram [<xref ref-type="bibr" rid="ref17">17</xref>].</p></list-item><list-item><p>Truth Initiative: an antismoking campaign that effectively used social media to reduce teen smoking rates through engaging content and interactive platforms [<xref ref-type="bibr" rid="ref18">18</xref>].</p></list-item></list></sec><sec id="s1-3"><title>Health Awareness</title><p>Health awareness is termed as &#x201C;Enhancing the ability of individuals to understand and use health information to make informed decisions about their health&#x201D; [<xref ref-type="bibr" rid="ref13">13</xref>]. Efforts for health awareness are varied and multifaceted, encompassing a wide range of activities aimed at educating the public about health issues, promoting healthy behaviors, and preventing diseases [<xref ref-type="bibr" rid="ref16">16</xref>]. Health awareness campaigns lead to early detection and timely intervention, which benefits individuals by lowering their health care expenses and reducing the financial burden on the health care system [<xref ref-type="bibr" rid="ref18">18</xref>]. Health awareness is generally performed using mass media, social media, posters, billboards, workshops, seminars, local outreach programs, influencers, and public figures [<xref ref-type="bibr" rid="ref12">12</xref>]. However, social media is most useful in the current era due to its cost-effectiveness and wider audience engagement [<xref ref-type="bibr" rid="ref17">17</xref>]. Social media allows targeted messaging based on demographics, interests, and online behavior [<xref ref-type="bibr" rid="ref19">19</xref>]. This ensures that health messages reach the people most likely to benefit from them. Moreover, the effectiveness of health awareness through social media can be measured in a few easy ways, such as the number of impressions, likes, shares, comments, hashtag usage, and so on [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>]. Hence, medical professionals can analyze the efficacy of their awareness messages. There have been several successful health awareness campaigns conducted through social media that have achieved significant outcomes (<xref ref-type="other" rid="box1">Textbox 1</xref>).</p><boxed-text id="box1"><title> Health care awareness campaigns.</title><list list-type="simple"><list-item><p><bold>ThisGirlCan (2015)</bold></p><list list-type="bullet"><list-item><p>Objective: Encourage women of all ages and backgrounds to be more physically active, regardless of their shape, size, or fitness level [<xref ref-type="bibr" rid="ref20">20</xref>].</p></list-item><list-item><p>Execution: The campaign featured real women participating in various physical activities, promoting the message that women should feel confident about being active regardless of societal pressures or body image concerns.</p></list-item><list-item><p>Platforms used: Instagram, Twitter, Facebook, and YouTube.</p></list-item><list-item><p>Outcomes:</p><list list-type="bullet"><list-item><p>Widespread engagement: The hashtag #ThisGirlCan was used millions of times, with significant engagement from women sharing their own stories and photos.</p></list-item><list-item><p>Behavioral change: The campaign was credited with encouraging over 2.8 million women in the United Kingdom to become more active.</p></list-item><list-item><p>Long-term impact: The campaign continued beyond its initial phase, evolving into a broader movement that still influences public attitudes towards women and fitness.</p></list-item></list></list-item></list></list-item></list><list list-type="simple"><list-item><p><bold>#BellLetsTalk (Ongoing)</bold></p><list list-type="bullet"><list-item><p>Objective: Raise awareness about mental health issues and reduce stigma around mental illness in Canada [<xref ref-type="bibr" rid="ref21">21</xref>].</p></list-item><list-item><p>Execution: For every tweet using the hashtag #BellLetsTalk, every text message sent by Bell customers, and every Facebook video view, Bell Canada donates 5 cents to mental health initiatives.</p></list-item><list-item><p>Platforms used: Twitter, Facebook, Instagram, and Snapchat.</p></list-item><list-item><p>Outcomes:</p><list list-type="bullet"><list-item><p>Record participation: The 2021 campaign saw 159 million interactions, raising nearly CAD $8 million (equivalent US $5.56 million) in a single day.</p></list-item><list-item><p>Sustained impact: Since its inception, the campaign has raised more than CAD $121 million (equivalent US $84.5 million) for mental health initiatives.</p></list-item><list-item><p>Increased conversations: The campaign has significantly increased public dialogue about mental health in Canada, contributing to reducing stigma and promoting mental wellness.</p></list-item></list></list-item></list></list-item></list></boxed-text></sec><sec id="s1-4"><title>Health Care Education</title><p>Health care education refers to a deeper understanding of specific health topics, including the causes, symptoms, prevention, and treatment of diseases and how to maintain or improve health [<xref ref-type="bibr" rid="ref20">20</xref>]. It involves having factual information and comprehension of health-related subjects [<xref ref-type="bibr" rid="ref17">17</xref>]. Health care education encourages regular check-ups, screenings, and vaccinations, leading to early detection of diseases and more effective prevention strategies [<xref ref-type="bibr" rid="ref19">19</xref>]. For those with chronic conditions such as diabetes, hypertension, or asthma, health care education is essential for managing symptoms, adhering to treatment plans, and avoiding complications [<xref ref-type="bibr" rid="ref13">13</xref>].</p><p>In resource-limited economies, insufficient health care education has been reported among the population, which impedes individuals&#x2019; ability to understand, access, and apply health information effectively [<xref ref-type="bibr" rid="ref21">21</xref>]. Moreover, low-income individuals may have less access to health resources, education, and information, which hinders their ability to acquire and apply health education [<xref ref-type="bibr" rid="ref22">22</xref>]. Addressing these barriers in resource-limited countries requires targeted strategies such as improving health literacy, offering culturally sensitive health care education, increasing access to technology, and combating misinformation [<xref ref-type="bibr" rid="ref21">21</xref>].</p><p>Among these targeted strategies, social media has gained the most attention in the high-income world [<xref ref-type="bibr" rid="ref20">20</xref>]. Health care education through social media has become an increasingly effective method for reaching diverse audiences with health information. Studies suggest that health care education campaigns on social media can achieve behavioral change success rates ranging from 20% to 40% [<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref17">17</xref>]. For instance, social media campaigns promoting COVID-19 vaccination have seen varying success, with some countries reporting a 15% to 25% increase in vaccine uptake attributable to social media efforts [<xref ref-type="bibr" rid="ref15">15</xref>]. Moreover, some campaigns that promote health services (eg, vaccination drives or mental health counseling) report conversion rates (actual service uptake) of 5% to 20%, depending on the call to action and the ease of access to the service [<xref ref-type="bibr" rid="ref18">18</xref>]. The existing literature has discussed a few notable health care education campaigns executed through social media and validated their impact. One such campaign for spreading health care education is The Amyotropic Lateral sclerosis (ALS) Ice Bucket Challenge (<xref ref-type="other" rid="box2">Textbox 2</xref>).</p><boxed-text id="box2"><title> Health care education campaigns through social media.</title><list list-type="order"><list-item><p>The ALS Ice Bucket Challenge (2014)</p></list-item></list><list list-type="bullet"><list-item><p>Overview: Participants dumped buckets of ice water over their heads, shared videos on social media, and nominated others to do the same, all to raise awareness and funds for Amyotrophic Lateral Sclerosis (ALS) research [<xref ref-type="bibr" rid="ref23">23</xref>].</p></list-item><list-item><p>Impact:</p><list list-type="bullet"><list-item><p>Financial: Raised over US $115 million for the ALS Association in just a few months.</p></list-item><list-item><p>Awareness: Dramatically increased global awareness of ALS, with millions participating worldwide.</p></list-item><list-item><p>Research Advancement: Funds contributed to significant research advancements, including the discovery of new ALS genes.</p></list-item></list></list-item></list></boxed-text></sec><sec id="s1-5"><title>Pakistan Context</title><p>In Pakistan, the Federal and provincial governments jointly administer 60% of the health care system, with the private sector contributing 30%. Autonomous bodies support the remaining 10 percent [<xref ref-type="bibr" rid="ref24">24</xref>]. The diverse structure and the country&#x2019;s economic challenges pose unique obstacles to effective health care delivery. The country&#x2019;s health care spending is at 2.95% of its Gross Domestic Product, and the Pakistani government always disregarded the economic survey data and faced criticism from the apex medical organization as it necessitated health allocations in line with global guidelines [<xref ref-type="bibr" rid="ref25">25</xref>]. To provide quality health care, the Pakistan Medical Association (PMA) expressed the need for 6% of the country&#x2019;s Gross Domestic Product allocation, as recommended by the World Health Organization [<xref ref-type="bibr" rid="ref17">17</xref>], which the country is unable to meet due to economic challenges [<xref ref-type="bibr" rid="ref26">26</xref>].</p><p>Due to these financial limitations, there are reported disparities in health awareness, with urban areas generally having better access than rural regions [<xref ref-type="bibr" rid="ref2">2</xref>]. Thus, communicable diseases, such as waterborne diseases and vector-borne diseases, remain a more significant concern in rural regions [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref3">3</xref>]. Moreover, with limited access to maternal health care and family planning services, Pakistan witnesses high maternal and child mortality rates [<xref ref-type="bibr" rid="ref2">2</xref>]. Diseases such as malaria, tuberculosis, and hepatitis are prevalent, which exacerbates the situation [<xref ref-type="bibr" rid="ref24">24</xref>]. Moreover, stigma about sexually transmitted infections results in inadequate prevention and treatment efforts that result in a psychological attack on patients [<xref ref-type="bibr" rid="ref25">25</xref>]. Poor sanitation and hygiene contribute to outbreaks of diseases like cholera and dysentery in Pakistan and many preventable diseases, such as polio and measles, persist due to low vaccination rates [<xref ref-type="bibr" rid="ref23">23</xref>].</p><p>Amid financial crises, health care awareness and education are known to be effective in reducing the disease burden rate [<xref ref-type="bibr" rid="ref8">8</xref>]. There are several traditional efforts made by the Government of Pakistan Ministry of Health in the past to improve disease awareness and reduce the patient burden [<xref ref-type="bibr" rid="ref24">24</xref>]. These include the following:</p><list list-type="order"><list-item><p>Engaging community health workers in disseminating health information, especially in rural areas. However, the number of community health workers to cover the target population is very limited and requires substantial spending [<xref ref-type="bibr" rid="ref24">24</xref>].</p></list-item><list-item><p>Use of radio and television for health awareness programs, public service announcements, and talk shows but requires financial resources [<xref ref-type="bibr" rid="ref27">27</xref>].</p></list-item><list-item><p>Newspapers, magazines, and pamphlets are also used to spread health information, but considering the low literacy rate and cost of print media, these are not found to be much effective for the target population [<xref ref-type="bibr" rid="ref27">27</xref>].</p></list-item></list><p>However, among the modern techniques, social media has gained much attention from health care communities globally [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref10">10</xref>]. Pakistan has also witnessed the widespread of social media but in academics, e-commerce, entertainment, media, politics, sports, and religious sectors. In Pakistan, 29.5% of the population is on social media, whereas 77.8% has active mobile connections, meaning these users also have access to social media platforms [<xref ref-type="bibr" rid="ref28">28</xref>].</p><p>The health care sector is structured to depend on government approval for any initiative [<xref ref-type="bibr" rid="ref29">29</xref>]. The government has not devised any legislation to promote the use of social media for awareness [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref27">27</xref>]. This mainly restricts the government&#x2019;s health departments and health care professionals from using this tool to publicize health messages. Some efforts have been made to digitalize the health care sector using the eHealth concept and implement a few apps to initiate telehealth and telemedicine [<xref ref-type="bibr" rid="ref30">30</xref>]. Also, mobile messaging and caller voice tunes are found to be significant in health care services awareness [<xref ref-type="bibr" rid="ref30">30</xref>]. However, the interpretation and usage of social media tools are still scarce [<xref ref-type="bibr" rid="ref31">31</xref>]. For this reason, it is imperative to investigate the social media usefulness among health care professionals in Pakistan and to identify whether these health care professionals support the use of social media for health awareness and education.</p></sec><sec id="s1-6"><title>Theoretical Foundation</title><p>A few theories explain the behaviors toward acceptance of any new digitalized tool and address their attitude [<xref ref-type="bibr" rid="ref32">32</xref>], including the innovation diffusion theory proposed by Rogers in 1962, the Theory of Reasoned Action proposed by Fishbein and Ajzen in 1967, the Self-Efficacy Theory proposed by Bandura in 1977, the Theory of Planned Behavior proposed by Ajzen in 1985, the Social Cognitive Theory proposed by Bandura in 1986, and the Technology Acceptance Model proposed by Davis in 1986 [<xref ref-type="bibr" rid="ref32">32</xref>]. Among these various behavioral theories, the Innovation Diffusion Theory (IDT) offers a framework for understanding how new ideas, behaviors, or innovations spread within a population [<xref ref-type="bibr" rid="ref33">33</xref>].</p><p>In public health, innovation diffusion theory helps explain how new health interventions, practices, or policies are adopted and disseminated within communities [<xref ref-type="bibr" rid="ref33">33</xref>]. The theory identifies 5 stages individuals and communities pass when adopting an innovation: knowledge, persuasion, decision, implementation, and confirmation [<xref ref-type="bibr" rid="ref34">34</xref>]. <xref ref-type="fig" rid="figure1">Figure 1</xref> explains these five stages of the innovation-decision process.</p><p>To understand social media acceptance for health awareness and education, the theory has categorized individuals within a population into subgroups based on their readiness to adopt innovations. Innovators and early adopters are likely to adopt innovations early, while most of the population follows suit over time. Laggards are the last to adopt [<xref ref-type="bibr" rid="ref33">33</xref>]. <xref ref-type="fig" rid="figure2">Figure 2</xref> explains these subgroups of individuals.</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>Innovation diffusion process.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="humanfactors_v12i1e65745_fig01.png"/></fig><fig position="float" id="figure2"><label>Figure 2.</label><caption><p>Adopter categories.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="humanfactors_v12i1e65745_fig02.png"/></fig><p>In health care education and awareness, the diffusion of innovation is used to fast-track the acceptance of crucial public health digitalized interventions that ordinarily intend to influence the behavior of a social system [<xref ref-type="bibr" rid="ref34">34</xref>]. Thus, this theory provides the foundation for understanding social media usage and its adoption attitude in a particular community.</p><p>In Pakistan, the ineffective innovation management approaches and deprived diffusion of innovation strategies are hurdles to realizing the importance of social media and its usage for health care education [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref25">25</xref>]. The deprived diffusion of innovation is a significant factor in the inability to attain the desired output. Even for digitalized hospital tools other than social media, the country needs more innovative and user-friendly equipment in the hospital sector [<xref ref-type="bibr" rid="ref25">25</xref>]. The notion of consistent health care challenges and inadequate health resources in Pakistan is also evident from the recent Joint External Evaluation report [<xref ref-type="bibr" rid="ref24">24</xref>].</p><p>For this reason, it is imperative to investigate the impact of social media&#x2019;s effective use on health awareness and health care education in Pakistan using IDT. This may result in highlighting and understanding the effectiveness of social media tools in reducing the disease burden in the country.</p><p><xref ref-type="fig" rid="figure3">Figure 3</xref> explains the theoretical framework of the current study.</p><fig position="float" id="figure3"><label>Figure 3.</label><caption><p>Conceptual framework of the study.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="humanfactors_v12i1e65745_fig03.png"/></fig><p>Hence, the current study hypotheses are:</p><list list-type="order"><list-item><p>Hypothesis 1 (H1): social media usefulness positively and significantly impacts health awareness in Pakistan.</p></list-item><list-item><p>Hypothesis 2 (H2): health awareness has a significant positive impact on health care education in Pakistan.</p></list-item></list></sec></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Instrument Development</title><p>A quantitative technique was applied to test the study hypothesis and validate the proposed model using the structural equation modeling (SEM) technique [<xref ref-type="bibr" rid="ref35">35</xref>]. SEM is deemed the most suitable due to its ability to simultaneously test complex relationships among multiple variables and validate the proposed conceptual model. Data analysis was carried out using AMOS 26.0 software (IBM Corp) [<xref ref-type="bibr" rid="ref36">36</xref>]. Since the study aims to identify social media&#x2019;s impact on health awareness leading to health care education and uses the IDT as a theoretical foundation, scales from previous literature have been adopted. The main advantage of adopting these scales is that they have already been validated in the health industry&#x2019;s acceptance behavior of new technological tools. For instance, the measurement scale for Innovative Technology (social media) usefulness was adopted from a previous study [<xref ref-type="bibr" rid="ref37">37</xref>], and measurement scales for health awareness have been adopted from another study [<xref ref-type="bibr" rid="ref38">38</xref>]. Aligning with the psychometric literature, 4-item scales for each construct based on their higher loadings have been adopted [<xref ref-type="bibr" rid="ref37">37</xref>]. The modified 8-item scale for measuring health care education was adopted based on the questionnaire of Ho et al [<xref ref-type="bibr" rid="ref39">39</xref>]. For the measurement of each item, a 7-point Likert scale ranging from 1 (strongly disagree) to 7 (strongly agree) was used [<xref ref-type="bibr" rid="ref38">38</xref>].</p></sec><sec id="s2-2"><title>Data Collection</title><p>A questionnaire was designed based on the variables of the present study, utilizing the aforementioned scales, which are provided in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>. A personally administered questionnaire was used for data collection [<xref ref-type="bibr" rid="ref32">32</xref>]. For data collection, the current research to eliminate targeted health care professionals and paramedic staff of 2 private hospitals in Lahore, Pakistan. The questionnaire was distributed to more than 450 health care professionals and paramedic staff using convenience sampling and requested their valuable feedback. However, only 389 useful responses were received.</p></sec><sec id="s2-3"><title>Ethical Considerations</title><p>As a matter of ethical concerns, prior permission from the hospital management was obtained, and the purpose of the study was explained to all respondents through &#x201C;informed consent.&#x201D; It was assured that respondents&#x2019; privacy would be ensured through confidentiality. Ethical approval was not required for this study as it did not involve identifiable personal data, or interventions falling under the scope of institutional or national ethics review requirements. In accordance with the Declaration of Helsinki (World Medical Association, 2013) research ethics policy, studies that do not involve sensitive data are exempt from formal ethics board approval.</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><sec id="s3-1"><title>Primary Data Screening</title><p>Initial screening was carried out among 389 useful responses to eliminate unusual responses, mainly incomplete questionnaires and respondents who marked similar scores on all items. Furthermore, questionnaires with more than 4 missing values were also excluded. The remaining missing values were replaced with the series mean/average for the rest of the responses. Therefore, the final useful sample was reduced to 340.</p><p><xref ref-type="table" rid="table1">Table 1</xref> provides the demographics of the study respondents. Among 340 respondents, 58% (197/340) were male, and the rest were female (143/340, 42%). A total of 91% (309/340) of the respondents were between 25 and 35 years of age, which may lead to the fact that most health care professionals and paramedic staff in private hospitals in Lahore are young. However, we may be unable to neglect the 6% of the population under 25 years old and more eager to start their career in the health care sector. The remaining 3% were more than 35 years of age and had extensive health industry work experience.</p><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>Sociodemographic characteristics of study respondents (N=340).</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom" colspan="2">Characteristics</td><td align="left" valign="top" colspan="2">Values, n (%)</td></tr></thead><tbody><tr><td align="left" valign="top" colspan="4">Sex</td></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Male</td><td align="left" valign="top" colspan="2">197 (58)</td></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Female</td><td align="left" valign="top" colspan="2">143 (42)</td></tr><tr><td align="left" valign="top" colspan="4">Age (years)</td></tr><tr><td align="char" char="." valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>&#x003C;25</td><td align="left" valign="top" colspan="2">21 (6)</td></tr><tr><td align="char" char="hyphen" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>25-35</td><td align="left" valign="top" colspan="2">309 (91)</td></tr><tr><td align="char" char="." valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>&#x003E;35</td><td align="left" valign="top" colspan="2">10 (3)</td></tr><tr><td align="left" valign="top" colspan="4">Social media experience (years)</td></tr><tr><td align="char" char="." valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>&#x003C;1</td><td align="left" valign="top" colspan="2">34 (10)</td></tr><tr><td align="char" char="hyphen" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>2-5</td><td align="left" valign="top" colspan="2">207 (61)</td></tr><tr><td align="char" char="." valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>&#x003E;5</td><td align="left" valign="top" colspan="2">99 (29)</td></tr><tr><td align="left" valign="top" colspan="4">Monthly income<sup><xref ref-type="table-fn" rid="table1fn1">a</xref></sup></td></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Less than PKR<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup> 40,000 (US $142.98)</td><td align="left" valign="top" colspan="2">101 (30)</td></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>PKR 40,000-80,000 (US $142.98-US $285.97)</td><td align="left" valign="top" colspan="2">197 (58)</td></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>More than 80,000 (US $285.97)</td><td align="left" valign="top" colspan="2">42 (12)</td></tr><tr><td align="left" valign="top" colspan="4">Education</td></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Less than secondary school</td><td align="left" valign="top" colspan="2">63 (18)</td></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Secondary school to graduation</td><td align="left" valign="top" colspan="2">259 (76)</td></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Medical (MBBS<sup><xref ref-type="table-fn" rid="table1fn3">c</xref></sup>/BDS)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup> or Masters degree</td><td align="left" valign="top" colspan="2">18 (6)</td></tr><tr><td align="left" valign="top" colspan="4">Health services experience (years)</td></tr><tr><td align="char" char="." valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>&#x003C;3</td><td align="left" valign="top" colspan="2">21 (6)</td></tr><tr><td align="char" char="hyphen" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>3-6</td><td align="left" valign="top" colspan="2">225 (66)</td></tr><tr><td align="char" char="." valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>&#x003E;6</td><td align="left" valign="top" colspan="2">94 (28)</td></tr></tbody></table><table-wrap-foot><fn id="table1fn1"><p><sup>a</sup>A currency exchange rate of US $1=280 PKR is applicable.</p></fn><fn id="table1fn2"><p><sup>b</sup>PKR: Pakistani rupees.</p></fn><fn id="table1fn3"><p><sup>c</sup>MBBS: Bachelor of Medicine, Bachelor of Surgery.</p></fn><fn id="table1fn4"><p><sup>d</sup>BDS: Bachelor of Dental Surgery.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-2"><title>Data Analysis</title><p>An exploratory factor analysis was initially performed on the 16 measurement items to confirm the underlying relationships [<xref ref-type="bibr" rid="ref36">36</xref>]. For sample adequacy, the KMO value (0.850) was greater than the recommended value (0.60), and the significance value of <italic>P</italic>0.001 confirmed the Bartlett test of sphericity, as shown in Table S1 in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>. All those factors were retained for data analysis, with factor loading greater than 0.50 and Eigenvalue greater than 1.0. Hence, this technique provided 3 factors that explained 72.2% of the variance after varimax rotation. Furthermore, scale reliability coefficients were greater than the acceptable value (0.70) [<xref ref-type="bibr" rid="ref40">40</xref>], and Shapiro-Wilk tests were conducted to check the data normality [<xref ref-type="bibr" rid="ref40">40</xref>], as shown in Table S2 in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref> . The results of both tests were significant, meaning there was no normality issue in the data.</p><p>For further data analysis, a two-stage structural equation modeling (SEM) technique was used [<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref38">38</xref>]. This approach allows researchers to evaluate the measurement and structural models separately using two dissimilar subsamples. For this reason, a sample of 340 participants was divided into two parts: a sample of 170 individuals was used for the measurement model, and a similar sample size was used for the structural model assessment to attain impartial results.</p></sec><sec id="s3-3"><title>Reliability and Validity Measures</title><p>According to Hair et al [<xref ref-type="bibr" rid="ref35">35</xref>], finding the reliability of each item and construct in the research study is essential. Therefore, squared multiple correlation (SMC) was used to find the reliability of each reliability item of each measurement item. SMC represents &#x201C;the amount of variance explained by an individual indicator/construct of its respective factor and measured by the square of its (indicator&#x2019;s) standardized factor loading&#x201D; [<xref ref-type="bibr" rid="ref40">40</xref>].</p><p>Hair [<xref ref-type="bibr" rid="ref35">35</xref>] indicated that the cutoff value of SMC is 0.30. Hence, it is evident from <xref ref-type="table" rid="table2">Table 2</xref> that all the SMC values are greater than 0.30. For measuring the reliability of each variable, the Cronbach alpha value was used. As suggested in the literature, the cutoff value of Cronbach alpha is 0.70 [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>]; it is evident from <xref ref-type="table" rid="table2">Table 2</xref> that all variables&#x2019; Cronbach alpha values are more than 0.70. Furthermore, Hair et al [<xref ref-type="bibr" rid="ref35">35</xref>] also highlighted that for measuring the convergent validity, there are three common approaches: (1) standardized factor loading (0.5 or greater), (2) average variance explained (0.5 or higher), and (3) composite reliability (0.7 or above).</p><table-wrap id="t2" position="float"><label>Table 2.</label><caption><p>Measurement of reliability and validity.</p></caption><table id="table2" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom" colspan="2">Constructs and item</td><td align="left" valign="bottom" colspan="2">Values, mean (SD)</td><td align="left" valign="bottom">Standardized factor loading</td><td align="left" valign="bottom"><italic>S</italic>quared multiple correlation</td><td align="left" valign="bottom">Composite reliability</td><td align="left" valign="bottom">Cronbach alpha</td><td align="left" valign="bottom">Average variance explained</td></tr></thead><tbody><tr><td align="left" valign="top" colspan="2">Social media usefulness (SMU)</td><td align="left" valign="top" colspan="2"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>SMU1</td><td align="left" valign="top" colspan="2">5.19 (1.65)</td><td align="left" valign="top">0.781</td><td align="left" valign="top">0.607</td><td align="left" valign="top">0.788</td><td align="left" valign="top">0.774</td><td align="left" valign="top">0.589</td></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>SMU2</td><td align="left" valign="top" colspan="2">5.33 (1.71)</td><td align="left" valign="top">0.780</td><td align="left" valign="top">0.687</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>SMU3</td><td align="left" valign="top" colspan="2">5.01 (1.12)</td><td align="left" valign="top">0.777</td><td align="left" valign="top">0.671</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>SMU4</td><td align="left" valign="top" colspan="2">5.05 (1.32)</td><td align="left" valign="top">0.787</td><td align="left" valign="top">0.646</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="2">Health awareness (HA)</td><td align="left" valign="top" colspan="2"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>HA1</td><td align="left" valign="top" colspan="2">5.45 (1.56)</td><td align="left" valign="top">0.859</td><td align="left" valign="top">0.677</td><td align="left" valign="top">0.769</td><td align="left" valign="top">0.773</td><td align="left" valign="top">0.592</td></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>HA2</td><td align="left" valign="top" colspan="2">5.98 (1.45)</td><td align="left" valign="top">0.874</td><td align="left" valign="top">0.681</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>HA3</td><td align="left" valign="top" colspan="2">5.39 (1.43)</td><td align="left" valign="top">0.881</td><td align="left" valign="top">0.675</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>HA4</td><td align="left" valign="top" colspan="2">5.51 (1.39)</td><td align="left" valign="top">0.867</td><td align="left" valign="top">0.654</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="2">Health care education (HED)</td><td align="left" valign="top" colspan="2"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>HED1</td><td align="left" valign="top" colspan="2">5.23 (1.77)</td><td align="left" valign="top">0.719</td><td align="left" valign="top">0.651</td><td align="left" valign="top">0.783</td><td align="left" valign="top">0.789</td><td align="left" valign="top">0.678</td></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>HED2</td><td align="left" valign="top" colspan="2">5.22 (1.74)</td><td align="left" valign="top">0.775</td><td align="left" valign="top">0.629</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>HED3</td><td align="left" valign="top" colspan="2">5.60 (1.64)</td><td align="left" valign="top">0.721</td><td align="left" valign="top">0.622</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>HED4</td><td align="left" valign="top" colspan="2">5.41 (1.49)</td><td align="left" valign="top">0.739</td><td align="left" valign="top">0.637</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>HED5</td><td align="left" valign="top" colspan="2">5.22 (1.15)</td><td align="left" valign="top">0.787</td><td align="left" valign="top">0.663</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>HED6</td><td align="left" valign="top" colspan="2">5.11 (1.23)</td><td align="left" valign="top">0.772</td><td align="left" valign="top">0.654</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>HED7</td><td align="left" valign="top" colspan="2">5.09 (1.43)</td><td align="left" valign="top">0.759</td><td align="left" valign="top">0.691</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top" colspan="2"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>HED8</td><td align="left" valign="top" colspan="2">5.32 (1.59)</td><td align="left" valign="top">0.768</td><td align="left" valign="top">0.609</td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr></tbody></table></table-wrap><p>Hence, each standardized factor loading was statistically significant (<italic>P</italic>&#x003C;.001), and values ranged from 0.719 to 0.881, thus validating adequate convergent validity as shown in <xref ref-type="table" rid="table2">Table 2</xref>. In addition, the average value explained (AVE) values and construct reliability were also more than their cut-off level of 0.5 and 0.7, respectively, and were statistically significant. Therefore, these measures confirm sufficient convergent validity.</p><p>A comparison of shared variance between factors with the average variance explained by individual factors was ensured for measuring the discriminant validity. The diagonal value should be greater than the non-diagonal value to confirm adequate discriminant validity [<xref ref-type="bibr" rid="ref40">40</xref>]. Hence, results given in Table S3 in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>indicates the correlation matrix of constructs, where non-diagonal elements are correlated among constructs and diagonal elements are the square root of average variance explained (AVE) by that construct and clearly explain that all three constructs differ.</p></sec><sec id="s3-4"><title>Measurement Model</title><p>Using statistical software AMOS 26.0, the measurement model&#x2019;s confirmatory factor analysis (CFA) was performed [<xref ref-type="bibr" rid="ref40">40</xref>,<xref ref-type="bibr" rid="ref41">41</xref>]. This provided a passable model fit for the primary measurement model (CMIN=1220.23; CMIN/DF=1.98; GFI=0.72; AGFI=0.80; NFI=0.81; CFI=0.826; RMR=0.089; RMSEA=0.082); however, the number of indicators per item was large; for instance, the number of indicators for health care education were 8. Consequently, 2 items were deleted for further refinement to obtain an adequate model fit through the CFA of the measurement model. This refinement was conducted by deleting items one by one, based on their standardized residual; that is, that item was first deleted, which had a larger error variance than their measurement items. Each item was carefully reviewed before deleting it to ensure that, from a theoretical viewpoint, its error variance also seemed rational. The refinement and assessment process for every construct was first evident by Churchill [<xref ref-type="bibr" rid="ref41">41</xref>]. Churchill defined this process as; &#x201C;Though this application may be satisfactory during the early stages of research on a construct, the use of factor analysis in a confirmatory fashion would seem better at later stages.&#x201D; Furthermore, Gerbing and Anderson&#x2019;s [<xref ref-type="bibr" rid="ref42">42</xref>] study also provided support to Churchill&#x2019;s argument and stated that; &#x201C;to demonstrate that an explicit evaluation of Unidimensionality is accomplished with a confirmatory factor analysis of the individual measures as specified by a multiple-indicator measurement model. Coefficient alpha is important in assessing reliability but does not assess dimensionality. Although item-total correlations and exploratory factor analysis can provide useful preliminary analyses, particularly in the absence of a sufficiently detailed theory, they do not directly assess unidimensionality. The reason is that a confirmatory factor analysis assesses the internal consistency and external consistency criteria of unidimensionality implied by the multiple-indicator measurement model.</p><p>Hence, this refinement process provided an adequate model fit (CMIN=357.62; the ratio of <italic>&#x03C7;</italic><sup>2</sup> to degree of freedom value (1.80) is remarkably less than its recommended value (5.0). CMIN/DF=1.80; GFI=0.90; AGFI=0.89; NFI=0:915; CFI=0:93; RMR=0:075; RMSEA=0:055) as shown in <xref ref-type="table" rid="table3">Table 3</xref>.</p><table-wrap id="t3" position="float"><label>Table 3.</label><caption><p>Structural equation modeling fit indices for the confirmatory factor analysis model.</p></caption><table id="table3" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Fit indices</td><td align="left" valign="bottom">Cut-off criteria</td><td align="left" valign="bottom">Results obtained</td></tr></thead><tbody><tr><td align="left" valign="top" colspan="3">Absolute fit indices</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Chi-square (<italic>df</italic>)</td><td align="left" valign="top">N/A<sup><xref ref-type="table-fn" rid="table3fn1">a</xref></sup></td><td align="left" valign="top">357.62 (170)</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content><italic>&#x03C7;</italic><sup>2</sup>/df (CMIN/DF)</td><td align="left" valign="top">&#x003C;5.00</td><td align="left" valign="top">1.800</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Root Mean Square Error of Approximation</td><td align="left" valign="top">&#x003C;0.06</td><td align="left" valign="top">0.055</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Goodness of Fit Index</td><td align="left" valign="top">&#x003E;0.85</td><td align="left" valign="top">0.900</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Adjusted Goodness of Fit Index</td><td align="left" valign="top">&#x003E;0.85</td><td align="left" valign="top">0.890</td></tr><tr><td align="left" valign="top" colspan="3">Incremental fit indices</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Buntler-Bonett Normed Fit Index</td><td align="left" valign="top">&#x003E;0.90</td><td align="left" valign="top">0.915</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Comparative Fit Index</td><td align="left" valign="top">&#x003E;0.93</td><td align="left" valign="top">0.930</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Tucker Lewis Index</td><td align="left" valign="top">&#x003E;0.90</td><td align="left" valign="top">0.941</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Incremental Fit Index</td><td align="left" valign="top">&#x003E;0.90</td><td align="left" valign="top">0.932</td></tr><tr><td align="left" valign="top" colspan="3">Parsimonious fit indices</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Parsimony Goodness-Fit Index</td><td align="left" valign="top">&#x003E;0.50</td><td align="left" valign="top">0.798</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Parsimony Normed Fit Index</td><td align="left" valign="top">&#x003E;0.50</td><td align="left" valign="top">0.848</td></tr></tbody></table><table-wrap-foot><fn id="table3fn1"><p><sup>a</sup>N/A: not applicable.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-5"><title>Structural Model</title><p>The research hypotheses were tested through structural model estimation [<xref ref-type="bibr" rid="ref40">40</xref>]. Therefore, a second subsample (n=170) was used and provided the adequate structural model fit (CMIN=488.6; CMIN/DF=1.85; GFI=0.861; AGFI=0.893; NFI=0.987; CFI=0.945; RMR=0:079; RMSEA=0.053) as shown in <xref ref-type="table" rid="table4">Table 4</xref>.</p><table-wrap id="t4" position="float"><label>Table 4.</label><caption><p>Hypothesized structural model fit indices.</p></caption><table id="table4" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Fit index</td><td align="left" valign="bottom">Cut-off criteria</td><td align="left" valign="bottom">Results obtained</td></tr></thead><tbody><tr><td align="left" valign="top" colspan="3">Absolute fit indices</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Chi-square (<italic>df</italic>)</td><td align="left" valign="top">N/A<sup><xref ref-type="table-fn" rid="table4fn1">a</xref></sup></td><td align="left" valign="top">488.6 (170)</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content><italic>&#x03C7;</italic><sup>2</sup>/df (CMIN/DF)</td><td align="left" valign="top">&#x003C;5.00</td><td align="left" valign="top">1.850</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Root Mean Square Error of Approximation</td><td align="left" valign="top">&#x003C;0.06</td><td align="left" valign="top">0.053</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Goodness of Fit Index</td><td align="left" valign="top">&#x003E;0.85</td><td align="left" valign="top">0.861</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Adjusted Goodness of Fit Index</td><td align="left" valign="top">&#x003E;0.85</td><td align="left" valign="top">0.893</td></tr><tr><td align="left" valign="top" colspan="3">Incremental fit indices</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Buntler-Bonett Normed Fit Index</td><td align="left" valign="top">&#x003E;0.90</td><td align="left" valign="top">0.987</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Comparative Fit Index</td><td align="left" valign="top">&#x003E;0.93</td><td align="left" valign="top">0.945</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Tucker Lewis Index</td><td align="left" valign="top">&#x003E;0.90</td><td align="left" valign="top">0.976</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Incremental Fit Index</td><td align="left" valign="top">&#x003E;0.90</td><td align="left" valign="top">0.943</td></tr><tr><td align="left" valign="top" colspan="3">Parsimonious fit indices</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Parsimony Goodness-Fit Index</td><td align="left" valign="top">&#x003E;0.50</td><td align="left" valign="top">0.680</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Parsimony Normed Fit Index</td><td align="left" valign="top">&#x003E;0.50</td><td align="left" valign="top">0.609</td></tr></tbody></table><table-wrap-foot><fn id="table4fn1"><p><sup>a</sup>N/A: not applicable.</p></fn></table-wrap-foot></table-wrap><p>Moreover, the significance of the hypothesis is shown in <xref ref-type="table" rid="table5">Table 5</xref>. Testing of H1 revealed that social media usefulness has a significant effect on health awareness (H1: <italic>&#x03B2;</italic>=.669, <italic>P</italic>&#x003C;.001), supporting the IDT proposed by Rogers. Testing of H2 also supplied similar significant outcomes to the current research model (H2: <italic>&#x03B2;</italic>=.557, <italic>P</italic>&#x003C;.001), confirming the findins of prior work.</p><table-wrap id="t5" position="float"><label>Table 5.</label><caption><p>Hypothesis testing results.</p></caption><table id="table5" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">S.no.</td><td align="left" valign="bottom">Impact of</td><td align="left" valign="bottom">Impact on</td><td align="left" valign="bottom">Hypothesis</td><td align="left" valign="bottom">Path coefficient</td><td align="left" valign="bottom"><italic>P</italic> value</td><td align="left" valign="bottom">Outcome</td></tr></thead><tbody><tr><td align="char" char="." valign="top">1</td><td align="left" valign="top">SMU<sup><xref ref-type="table-fn" rid="table5fn1">a</xref></sup></td><td align="left" valign="top">HA<sup><xref ref-type="table-fn" rid="table5fn2">b</xref></sup></td><td align="left" valign="top">H1<sup><xref ref-type="table-fn" rid="table5fn3">c</xref></sup></td><td align="left" valign="top">0.669<sup><xref ref-type="table-fn" rid="table5fn4">d</xref></sup></td><td align="left" valign="top">.001</td><td align="left" valign="top">Significant impact</td></tr><tr><td align="char" char="." valign="top">2</td><td align="left" valign="top">HA</td><td align="left" valign="top">HED<sup><xref ref-type="table-fn" rid="table5fn5">e</xref></sup></td><td align="left" valign="top">H2<sup><xref ref-type="table-fn" rid="table5fn6">f</xref></sup></td><td align="left" valign="top">0.557<sup><xref ref-type="table-fn" rid="table5fn4">d</xref></sup></td><td align="left" valign="top">.001</td><td align="left" valign="top">Significant impact</td></tr></tbody></table><table-wrap-foot><fn id="table5fn1"><p><sup>a</sup>SMU: social media usefulness.</p></fn><fn id="table5fn2"><p><sup>b</sup>HA: health awareness.</p></fn><fn id="table5fn3"><p><sup>c</sup>H1: hypothesis 1.</p></fn><fn id="table5fn4"><p><sup>d</sup><italic>P</italic>&#x003C;.001.</p></fn><fn id="table5fn5"><p><sup>e</sup>HED: health care education.</p></fn><fn id="table5fn6"><p><sup>f</sup>H2: hypothesis 2.</p></fn></table-wrap-foot></table-wrap></sec></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><sec id="s4-1"><title>Principal Findings</title><p>This study examined the impact of social media on health awareness and its role in health care education, using IDT as the theoretical framework in Pakistan. A conceptual model was developed to assess the mediating effect of health awareness on the relationship between social media usage and health care education. The hypothesis testing results demonstrated significant relationships, with social media positively influencing health awareness (H<sub>1</sub>: path coefficient=0.669, <italic>P</italic>&#x003C;.001) and health awareness positively impacting health care education (H<sub>2</sub>: path coefficient=0.557, <italic>P</italic>&#x003C;.001). These findings highlight the potential of social media as an effective tool for promoting health care education when strategically leveraged by health care stakeholders.</p><p>The study also revealed that younger and more educated health staff are more inclined to use social media, while older groups, though recognizing its usefulness, engage less actively. This demographic insight underlines the need for tailored engagement strategies to maximize participation. Limited research in developing countries, including Pakistan, has tested the application of IDT to health care professionals&#x2019; adoption of social media for health care education. The standardized direct effects from hypothesis testing affirm the significant relationship between social media usefulness, health awareness, and health care education in the Pakistani context.</p><p>Given that developing countries are often classified as late adopters of technology, according to IDT, the findings emphasize the importance of region-specific social media content on platforms, such as Facebook, WhatsApp, or locally developed alternatives, for health care interventions. IDT further suggests that simplifying innovations can facilitate broader adoption, making it easier for health care professionals and the general population to engage with digital health initiatives. These insights highlight the need for cost-effective, user-centric solutions to enhance healthcare outcomes in Pakistan.</p><p>The government of Pakistan can also play a significant role in spreading health awareness. They can use social media to run campaigns on maternal health, child nutrition, and disease prevention. The health care professionals in private hospitals also indicated that live sessions and webinars on platforms like Facebook Live and Instagram Live to educate the patients and hospital staff on various health issues and answer their real-time questions have been very useful.</p><p>Using social media for health care education in Pakistan could be a game-changer, surpassing the expectations of spreading awareness regarding health needs in a particular community. This potential is not just theoretical; it has been proven in developed countries, such as the US, Jordan, the United Kingdom, and Europe, where social media was used during the COVID-19 pandemic to combat the pandemic and other notable diseases [<xref ref-type="bibr" rid="ref15">15</xref>]. Moreover, social media platforms have been used to promote telemedicine services, enabling health care professionals to connect with patients remotely for consultations, follow-ups, and monitoring of chronic conditions [<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref30">30</xref>].</p><p>Overall, this study validates the use of social media to improve public health care education through public awareness. Therefore, the study concludes that health care professionals should use social media tools to inform the wider public and address healthcare issues in Pakistan.</p></sec><sec id="s4-2"><title>Conclusion</title><p>The findings of this study underscore the significant role that social media plays in enhancing health care awareness and education among various populations in developing countries like Pakistan. With their wide reach and interactive features, social media platforms have proven to be effective tools for disseminating health-related information and engaging individuals in meaningful health conversations. Social media breaks down geographical barriers, allowing health information to reach a global audience instantly. This broadens the scope of health care awareness campaigns and makes information accessible to a diverse demographic, including those in remote or underserved areas. The interactive nature of social media facilitates active engagement between health care providers and the public. This interaction fosters a sense of community, encourages the sharing of personal health experiences, and allows for immediate feedback and clarification of health information. Also, social media platforms enable the dissemination of personalized health information tailored to specific audiences&#x2019; needs. Moreover, the real-time nature of these platforms ensures that information is up to date, which is crucial during health emergencies or outbreaks.</p><p>Health care education through social media can help understand how to prevent common diseases such as malaria, tuberculosis, hepatitis, and polio through vaccination, sanitation, and hygiene in Pakistan. Awareness campaigns can encourage healthier lifestyles, reducing the incidence of chronic diseases such as diabetes, hypertension, and heart disease. Educating women about prenatal and postnatal care, safe delivery practices, and child nutrition can significantly lower maternal and infant mortality rates. Awareness through social media about proper nutrition, immunization, and hygiene practices helps improve children&#x2019;s health and development in the rural outskirts of Pakistan. Also, awareness about communicable diseases and their transmission can help in preventing outbreaks of diseases like HIV/AIDS, tuberculosis, and waterborne illnesses.</p><p>Governmental policies provide a framework for regulating the content shared on social media, ensuring that the information disseminated is accurate, reliable, and in line with public health guidelines. Information shared by government-endorsed social media accounts is more likely to be trusted by the public. Official policies lend credibility and legitimacy to health messages, increasing the likelihood of public acceptance and compliance. All active organizations (govt and private) working in the health industry of Pakistan seek prior permission or ethical clearance to initiate any new work. Without government support, the organizations lack the confidence to spread and advertise any health-related content due to fear that they may be subject to local resistance.</p><p>Despite its benefits, the use of social media in health care awareness also presents challenges, such as the spread of misinformation and the need for privacy and data protection. Health care organizations must implement strategies to verify information and ensure the credibility of the content shared. Hence, the study suggests that Pakistan&#x2019;s health care organizations should continue leveraging social media to enhance health communication strategies and education. Ongoing research is also needed to explore new ways to maximize social media&#x2019;s benefits while mitigating its risks.</p><p>In conclusion, social media is a powerful tool for health care awareness, offering unprecedented opportunities to reach and engage with a wide audience. By harnessing its potential in developing economies, health care organizations can improve public health literacy, promote healthy behaviors, and ultimately contribute to better health outcomes. Collaborative efforts between health care professionals, social media platforms, and policymakers will be crucial in leveraging social media&#x2019;s full potential for public health advancement.</p></sec><sec id="s4-3"><title>Future Research</title><p>Future research should move beyond compliance with existing social media policies to explore strategies and variables that demonstrate tangible improvements in the health care sector. This could include investigating how social media can influence enhanced patient outcomes through better communication and engagement, broaden health awareness campaigns by targeting diverse and underserved populations, and improve access to health care services through innovative digital solutions. Additionally, longitudinal studies examining the long-term impact of social media interventions on public health indicators would provide valuable insights. Identifying and analyzing these variables will contribute to a more comprehensive understanding of social media&#x2019;s transformative potential in health care beyond mere policy adherence.</p></sec></sec></body><back><ack><p>The authors would like to thank Mr Nabil Ahmed, Director at Integral Global Consulting LLC, Tucker, GA, US for providing the necessary resources and facilities that enabled the successful execution of this research. The authors also want to extend their special thanks to all the respondents and hospital management in Lahore, Pakistan, for their feedback and the collaborative environment that fostered productive discussions and the exchange of ideas.</p></ack><fn-group><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">AGFI</term><def><p>Adjusted Goodness of Fit Index</p></def></def-item><def-item><term id="abb2">AVE</term><def><p>average value explained</p></def></def-item><def-item><term id="abb3">CFA</term><def><p>confirmatory factor analysis</p></def></def-item><def-item><term id="abb4">CFI</term><def><p>Comparative Fit Index</p></def></def-item><def-item><term id="abb5">CMIN</term><def><p>chi-square minimum</p></def></def-item><def-item><term id="abb6">DF</term><def><p>degrees of freedom</p></def></def-item><def-item><term id="abb7">GFI</term><def><p>Goodness of Fit</p></def></def-item><def-item><term id="abb8">H1</term><def><p>hypothesis 1</p></def></def-item><def-item><term id="abb9">H2</term><def><p>hypothesis 2</p></def></def-item><def-item><term id="abb10">IDT</term><def><p>Innovation Diffusion Theory</p></def></def-item><def-item><term id="abb11">NFI</term><def><p>Buntler-Bonett Normed Fit Index</p></def></def-item><def-item><term id="abb12">PMA</term><def><p>Pakistan Medical Association</p></def></def-item><def-item><term id="abb13">RMR</term><def><p>Root Mean Square Residual</p></def></def-item><def-item><term id="abb14">RMSEA</term><def><p>Root Mean Square Error of Approximation</p></def></def-item><def-item><term id="abb15">SEM</term><def><p>structural equation modeling</p></def></def-item><def-item><term id="abb16">SMC</term><def><p>squared multiple correlation</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Shaeen</surname><given-names>SK</given-names> </name><name name-style="western"><surname>Tharwani</surname><given-names>ZH</given-names> </name><name name-style="western"><surname>Bilal</surname><given-names>W</given-names> </name><name name-style="western"><surname>Islam</surname><given-names>Z</given-names> </name><name name-style="western"><surname>Essar</surname><given-names>MY</given-names> </name></person-group><article-title>Maternal mortality in Pakistan: challenges, efforts, and recommendations</article-title><source>Ann Med Surg (Lond)</source><year>2022</year><month>09</month><volume>81</volume><fpage>104380</fpage><pub-id pub-id-type="doi">10.1016/j.amsu.2022.104380</pub-id><pub-id pub-id-type="medline">36042926</pub-id></nlm-citation></ref><ref id="ref2"><label>2</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Hanif</surname><given-names>M</given-names> </name><name name-style="western"><surname>Khalid</surname><given-names>S</given-names> </name><name name-style="western"><surname>Rasul</surname><given-names>A</given-names> </name><name name-style="western"><surname>Mahmood</surname><given-names>K</given-names> </name></person-group><article-title>Maternal mortality in rural areas of Pakistan: challenges and prospects</article-title><source>Rural Health</source><year>2021</year><volume>7</volume><pub-id pub-id-type="doi">10.5772/intechopen.96934</pub-id></nlm-citation></ref><ref id="ref3"><label>3</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Soofi</surname><given-names>SB</given-names> </name><name name-style="western"><surname>Khan</surname><given-names>A</given-names> </name><name name-style="western"><surname>Kureishy</surname><given-names>S</given-names> </name><etal/></person-group><article-title>Determinants of stunting among children under five in Pakistan</article-title><source>Nutrients</source><year>2023</year><month>08</month><day>7</day><volume>15</volume><issue>15</issue><fpage>3480</fpage><pub-id pub-id-type="doi">10.3390/nu15153480</pub-id><pub-id pub-id-type="medline">37571417</pub-id></nlm-citation></ref><ref id="ref4"><label>4</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Bul</surname><given-names>K</given-names> </name><name name-style="western"><surname>Holliday</surname><given-names>N</given-names> </name><name name-style="western"><surname>Bhuiyan</surname><given-names>MRA</given-names> </name><name name-style="western"><surname>Clark</surname><given-names>CCT</given-names> </name><name name-style="western"><surname>Allen</surname><given-names>J</given-names> </name><name name-style="western"><surname>Wark</surname><given-names>PA</given-names> </name></person-group><article-title>Usability and preliminary efficacy of an artificial intelligence-driven platform supporting dietary management in diabetes: mixed methods study</article-title><source>JMIR Hum Factors</source><year>2023</year><month>08</month><day>9</day><volume>10</volume><fpage>e43959</fpage><pub-id pub-id-type="doi">10.2196/43959</pub-id><pub-id pub-id-type="medline">37556198</pub-id></nlm-citation></ref><ref id="ref5"><label>5</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Siddiqi</surname><given-names>DA</given-names> </name><name name-style="western"><surname>Ali</surname><given-names>RF</given-names> </name><name name-style="western"><surname>Shah</surname><given-names>MT</given-names> </name><etal/></person-group><article-title>Evaluation of a mobile-based immunization decision support system for scheduling age-appropriate vaccine schedules for children younger than 2 years in Pakistan and Bangladesh: lessons from a multisite, mixed methods study</article-title><source>JMIR Pediatr Parent</source><year>2023</year><month>02</month><day>17</day><volume>6</volume><fpage>e40269</fpage><pub-id pub-id-type="doi">10.2196/40269</pub-id><pub-id pub-id-type="medline">36800221</pub-id></nlm-citation></ref><ref id="ref6"><label>6</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Mo</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Pham</surname><given-names>TM</given-names> </name><name name-style="western"><surname>Lim</surname><given-names>C</given-names> </name><etal/></person-group><article-title>The effect of hand hygiene frequency on reducing acute respiratory infections in the community: a meta-analysis</article-title><source>Epidemiol Infect</source><year>2022</year><volume>150</volume><fpage>e79</fpage><pub-id pub-id-type="doi">10.1017/S0950268822000516</pub-id></nlm-citation></ref><ref id="ref7"><label>7</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Eaton</surname><given-names>MC</given-names> </name><name name-style="western"><surname>Probst</surname><given-names>YC</given-names> </name><name name-style="western"><surname>Smith</surname><given-names>MA</given-names> </name></person-group><article-title>Characterizing the discourse of popular diets to describe information dispersal and identify leading voices, interaction, and themes of mental health: social network analysis</article-title><source>JMIR Infodemiology</source><year>2023</year><month>05</month><day>5</day><volume>3</volume><fpage>e38245</fpage><pub-id pub-id-type="doi">10.2196/38245</pub-id><pub-id pub-id-type="medline">37159259</pub-id></nlm-citation></ref><ref id="ref8"><label>8</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Allegranzi</surname><given-names>B</given-names> </name><name name-style="western"><surname>Tartari</surname><given-names>E</given-names> </name><name name-style="western"><surname>Pittet</surname><given-names>D</given-names> </name></person-group><article-title>&#x2018;Seconds SAVE LIVES &#x2013; clean your hands&#x2019;: the 5 May 2021 World Health Organization&#x2019;s SAVE LIVES: Clean Your Hands campaign</article-title><source>Int J Infect Control</source><year>2021</year><volume>17</volume><issue>1</issue><fpage>21418</fpage><pub-id pub-id-type="doi">10.3396/ijic.v17.21418</pub-id></nlm-citation></ref><ref id="ref9"><label>9</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Subramanyam</surname><given-names>C</given-names> </name><name name-style="western"><surname>Becker</surname><given-names>A</given-names> </name><name name-style="western"><surname>Rizzo</surname><given-names>J</given-names> </name><name name-style="western"><surname>Afzal</surname><given-names>N</given-names> </name><name name-style="western"><surname>Nong</surname><given-names>Y</given-names> </name><name name-style="western"><surname>Sivamani</surname><given-names>R</given-names> </name></person-group><article-title>Visibility of board-certified dermatologists on TikTok</article-title><source>JMIR Dermatol</source><year>2024</year><month>01</month><day>5</day><volume>7</volume><fpage>e46085</fpage><pub-id pub-id-type="doi">10.2196/46085</pub-id><pub-id pub-id-type="medline">38180786</pub-id></nlm-citation></ref><ref id="ref10"><label>10</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Griffis</surname><given-names>HM</given-names> </name><name name-style="western"><surname>Kilaru</surname><given-names>AS</given-names> </name><name name-style="western"><surname>Werner</surname><given-names>RM</given-names> </name><etal/></person-group><article-title>Use of social media across US hospitals: descriptive analysis of adoption and utilization</article-title><source>J Med Internet Res</source><year>2014</year><month>11</month><day>27</day><volume>16</volume><issue>11</issue><fpage>e264</fpage><pub-id pub-id-type="doi">10.2196/jmir.3758</pub-id><pub-id pub-id-type="medline">25431831</pub-id></nlm-citation></ref><ref id="ref11"><label>11</label><nlm-citation citation-type="web"><article-title>Global social media statistics</article-title><source>DATAREPORTAL</source><access-date>2025-03-25</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://datareportal.com/social-media-users">https://datareportal.com/social-media-users</ext-link></comment></nlm-citation></ref><ref id="ref12"><label>12</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Terrasse</surname><given-names>M</given-names> </name><name name-style="western"><surname>Gorin</surname><given-names>M</given-names> </name><name name-style="western"><surname>Sisti</surname><given-names>D</given-names> </name></person-group><article-title>Social media, e-health, and medical ethics</article-title><source>Hastings Cent Rep</source><year>2019</year><month>01</month><volume>49</volume><issue>1</issue><fpage>24</fpage><lpage>33</lpage><pub-id pub-id-type="doi">10.1002/hast.975</pub-id><pub-id pub-id-type="medline">30790306</pub-id></nlm-citation></ref><ref id="ref13"><label>13</label><nlm-citation citation-type="confproc"><person-group person-group-type="author"><name name-style="western"><surname>Smith</surname><given-names>MA</given-names> </name></person-group><article-title>NodeXL: simple network analysis for social media</article-title><conf-name>Proceedings of the 2013 International Conference on Collaboration Technologies and Systems (CTS)</conf-name><conf-date>May 20-24, 2013</conf-date><conf-loc>San Diego, CA, USA</conf-loc><comment><ext-link ext-link-type="uri" xlink:href="https://ieeexplore.ieee.org/document/6567211">https://ieeexplore.ieee.org/document/6567211</ext-link></comment></nlm-citation></ref><ref id="ref14"><label>14</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Bazzano</surname><given-names>AN</given-names> </name><name name-style="western"><surname>Patel</surname><given-names>T</given-names> </name><name name-style="western"><surname>Nauman</surname><given-names>E</given-names> </name><name name-style="western"><surname>Cernigliaro</surname><given-names>D</given-names> </name><name name-style="western"><surname>Shi</surname><given-names>L</given-names> </name></person-group><article-title>Optimizing telehealth for diabetes management in the deep south of the United States: qualitative study of barriers and facilitators on the patient and clinician journey</article-title><source>J Med Internet Res</source><year>2024</year><month>01</month><day>1</day><volume>26</volume><fpage>e43583</fpage><pub-id pub-id-type="doi">10.2196/43583</pub-id><pub-id pub-id-type="medline">37976468</pub-id></nlm-citation></ref><ref id="ref15"><label>15</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Balki</surname><given-names>E</given-names> </name><name name-style="western"><surname>Holland</surname><given-names>C</given-names> </name><name name-style="western"><surname>Hayes</surname><given-names>N</given-names> </name></person-group><article-title>Use and acceptance of digital communication technology by older adults for social connectedness during the COVID-19 pandemic: mixed methods study</article-title><source>J Med Internet Res</source><year>2023</year><month>08</month><day>2</day><volume>25</volume><fpage>e41535</fpage><pub-id pub-id-type="doi">10.2196/41535</pub-id><pub-id pub-id-type="medline">37531187</pub-id></nlm-citation></ref><ref id="ref16"><label>16</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Santos</surname><given-names>DS</given-names> </name><name name-style="western"><surname>Batistelli</surname><given-names>CRS</given-names> </name><name name-style="western"><surname>Lara</surname><given-names>MMDS</given-names> </name><name name-style="western"><surname>Ferreira</surname><given-names>E de S</given-names> </name><name name-style="western"><surname>Moreira</surname><given-names>TR</given-names> </name><name name-style="western"><surname>Cotta</surname><given-names>RMM</given-names> </name></person-group><article-title>The effectiveness of the use of telehealth programs in the care of individuals with hypertension and, or diabetes mellitus: systematic review and meta-analysis</article-title><source>Diabetol Metab Syndr</source><year>2022</year><month>05</month><day>28</day><volume>14</volume><issue>1</issue><fpage>76</fpage><pub-id pub-id-type="doi">10.1186/s13098-022-00846-5</pub-id><pub-id pub-id-type="medline">35643495</pub-id></nlm-citation></ref><ref id="ref17"><label>17</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Lenoir</surname><given-names>P</given-names> </name><name name-style="western"><surname>Moulahi</surname><given-names>B</given-names> </name><name name-style="western"><surname>Az&#x00E9;</surname><given-names>J</given-names> </name><name name-style="western"><surname>Bringay</surname><given-names>S</given-names> </name><name name-style="western"><surname>Mercier</surname><given-names>G</given-names> </name><name name-style="western"><surname>Carbonnel</surname><given-names>F</given-names> </name></person-group><article-title>Raising awareness about cervical cancer using Twitter: content analysis of the 2015 #SmearForSmear campaign</article-title><source>J Med Internet Res</source><year>2017</year><month>10</month><day>16</day><volume>19</volume><issue>10</issue><fpage>e344</fpage><pub-id pub-id-type="doi">10.2196/jmir.8421</pub-id><pub-id pub-id-type="medline">29038096</pub-id></nlm-citation></ref><ref id="ref18"><label>18</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Niederdeppe</surname><given-names>J</given-names> </name><name name-style="western"><surname>Farrelly</surname><given-names>MC</given-names> </name><name name-style="western"><surname>Haviland</surname><given-names>ML</given-names> </name></person-group><article-title>Confirming &#x201C;truth&#x201D;: more evidence of a successful tobacco countermarketing campaign in Florida</article-title><source>Am J Public Health</source><year>2004</year><month>02</month><volume>94</volume><issue>2</issue><fpage>255</fpage><lpage>257</lpage><pub-id pub-id-type="doi">10.2105/ajph.94.2.255</pub-id><pub-id pub-id-type="medline">14759936</pub-id></nlm-citation></ref><ref id="ref19"><label>19</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Maher</surname><given-names>CA</given-names> </name><name name-style="western"><surname>Lewis</surname><given-names>LK</given-names> </name><name name-style="western"><surname>Ferrar</surname><given-names>K</given-names> </name><name name-style="western"><surname>Marshall</surname><given-names>S</given-names> </name><name name-style="western"><surname>De Bourdeaudhuij</surname><given-names>I</given-names> </name><name name-style="western"><surname>Vandelanotte</surname><given-names>C</given-names> </name></person-group><article-title>Are health behavior change interventions that use online social networks effective? A systematic review</article-title><source>J Med Internet Res</source><year>2014</year><month>02</month><day>14</day><volume>16</volume><issue>2</issue><fpage>e40</fpage><pub-id pub-id-type="doi">10.2196/jmir.2952</pub-id><pub-id pub-id-type="medline">24550083</pub-id></nlm-citation></ref><ref id="ref20"><label>20</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Bauman</surname><given-names>A</given-names> </name><name name-style="western"><surname>McNeil</surname><given-names>N</given-names> </name><name name-style="western"><surname>Nicholson</surname><given-names>M</given-names> </name><etal/></person-group><article-title>Impact of the first year of the &#x201C;This girl can&#x201D; physical activity and sport mass media campaign in Australia</article-title><source>BMC Public Health</source><year>2023</year><month>02</month><day>15</day><volume>23</volume><issue>1</issue><fpage>333</fpage><pub-id pub-id-type="doi">10.1186/s12889-023-15091-2</pub-id><pub-id pub-id-type="medline">36793043</pub-id></nlm-citation></ref><ref id="ref21"><label>21</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Booth</surname><given-names>RG</given-names> </name><name name-style="western"><surname>Allen</surname><given-names>BN</given-names> </name><name name-style="western"><surname>Bray Jenkyn</surname><given-names>KM</given-names> </name><name name-style="western"><surname>Li</surname><given-names>L</given-names> </name><name name-style="western"><surname>Shariff</surname><given-names>SZ</given-names> </name></person-group><article-title>Youth mental health services utilization rates after a large-scale social media campaign: population-based interrupted time-series analysis</article-title><source>JMIR Ment Health</source><year>2018</year><month>04</month><day>6</day><volume>5</volume><issue>2</issue><fpage>e27</fpage><pub-id pub-id-type="doi">10.2196/mental.8808</pub-id><pub-id pub-id-type="medline">29625954</pub-id></nlm-citation></ref><ref id="ref22"><label>22</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Stronks</surname><given-names>K</given-names> </name><name name-style="western"><surname>van de Mheen</surname><given-names>HD</given-names> </name><name name-style="western"><surname>Mackenbach</surname><given-names>JP</given-names> </name></person-group><article-title>A higher prevalence of health problems in low income groups: does it reflect relative deprivation?</article-title><source>J Epidemiol Community Health</source><year>1998</year><month>09</month><volume>52</volume><issue>9</issue><fpage>548</fpage><lpage>557</lpage><pub-id pub-id-type="doi">10.1136/jech.52.9.548</pub-id><pub-id pub-id-type="medline">10320855</pub-id></nlm-citation></ref><ref id="ref23"><label>23</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Song</surname><given-names>P</given-names> </name></person-group><article-title>The Ice Bucket Challenge: the public sector should get ready to promptly promote the sustained development of a system of medical care for and research into rare diseases</article-title><source>Intractable Rare Dis Res</source><year>2014</year><month>08</month><volume>3</volume><issue>3</issue><fpage>94</fpage><lpage>96</lpage><pub-id pub-id-type="doi">10.5582/irdr.2014.01015</pub-id><pub-id pub-id-type="medline">25364651</pub-id></nlm-citation></ref><ref id="ref24"><label>24</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Khan</surname><given-names>SJ</given-names> </name><name name-style="western"><surname>Asif</surname><given-names>M</given-names> </name><name name-style="western"><surname>Aslam</surname><given-names>S</given-names> </name><name name-style="western"><surname>Khan</surname><given-names>WJ</given-names> </name><name name-style="western"><surname>Hamza</surname><given-names>SA</given-names> </name></person-group><article-title>Pakistan&#x2019;s healthcare system:a review of major challenges and the first comprehensive universal health coverage initiative</article-title><source>Cureus</source><year>2023</year><month>09</month><volume>15</volume><issue>9</issue><fpage>e44641</fpage><pub-id pub-id-type="doi">10.7759/cureus.44641</pub-id><pub-id pub-id-type="medline">37799252</pub-id></nlm-citation></ref><ref id="ref25"><label>25</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Naz</surname><given-names>F</given-names> </name><name name-style="western"><surname>Asghar</surname><given-names>K</given-names> </name></person-group><article-title>Patients satisfaction and healthcare delivery system in public sector hospitals</article-title><source>Pak Soc Sci Rev</source><year>2023</year><month>07</month><volume>7</volume><issue>3</issue><fpage>352</fpage><lpage>362</lpage><pub-id pub-id-type="doi">10.35484/pssr.2023(7-III)28</pub-id></nlm-citation></ref><ref id="ref26"><label>26</label><nlm-citation citation-type="web"><article-title>PMA expresses grave concern over deteriorating health indicators</article-title><source>BOL News</source><access-date>2025-03-25</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://www.pmacentre.org.pk/new/Newscuttings%2010-06-2023%20-%20Health%20Indicators.pdf">https://www.pmacentre.org.pk/new/Newscuttings%2010-06-2023%20-%20Health%20Indicators.pdf</ext-link></comment></nlm-citation></ref><ref id="ref27"><label>27</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Saleem</surname><given-names>A</given-names> </name><name name-style="western"><surname>Rizvi</surname><given-names>WR</given-names> </name><name name-style="western"><surname>Farrukh</surname><given-names>M</given-names> </name><name name-style="western"><surname>Saleem</surname><given-names>M</given-names> </name></person-group><article-title>Influence of radio programs on development of small &#x0026; medium enterprises in central Punjab Pakistan</article-title><source>PalArch&#x2019;s J Archaeol Egypt/ Egyptol</source><year>2021</year><volume>18</volume><issue>10</issue><fpage>116</fpage><lpage>140</lpage></nlm-citation></ref><ref id="ref28"><label>28</label><nlm-citation citation-type="web"><person-group person-group-type="author"><collab>Global Social Media Statistics</collab></person-group><article-title>Pakistan</article-title><access-date>2025-03-25</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://datareportal.com/reports/digital-2024pakistan#:~:text=Pakistan%20was%20home%20to%2071.70,percent%20of%20the%20total%20population">https://datareportal.com/reports/digital-2024pakistan#:~:text=Pakistan%20was%20home%20to%2071.70,percent%20of%20the%20total%20population</ext-link></comment></nlm-citation></ref><ref id="ref29"><label>29</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Shaikh</surname><given-names>BT</given-names> </name><name name-style="western"><surname>Ali</surname><given-names>N</given-names> </name></person-group><article-title>Universal health coverage in Pakistan: is the health system geared up to take on the challenge?</article-title><source>Global Health</source><year>2023</year><month>01</month><day>12</day><volume>19</volume><issue>1</issue><fpage>4</fpage><pub-id pub-id-type="doi">10.1186/s12992-023-00904-1</pub-id><pub-id pub-id-type="medline">36635698</pub-id></nlm-citation></ref><ref id="ref30"><label>30</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Bilal</surname><given-names>W</given-names> </name><name name-style="western"><surname>Qamar</surname><given-names>K</given-names> </name><name name-style="western"><surname>Siddiqui</surname><given-names>A</given-names> </name><name name-style="western"><surname>Kumar</surname><given-names>P</given-names> </name><name name-style="western"><surname>Essar</surname><given-names>MY</given-names> </name></person-group><article-title>Digital health and telemedicine in Pakistan: Improving maternal healthcare</article-title><source>Ann Med Surg (Lond)</source><year>2022</year><month>09</month><volume>81</volume><fpage>104425</fpage><pub-id pub-id-type="doi">10.1016/j.amsu.2022.104425</pub-id><pub-id pub-id-type="medline">36046714</pub-id></nlm-citation></ref><ref id="ref31"><label>31</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Ittefaq</surname><given-names>M</given-names> </name><name name-style="western"><surname>Seo</surname><given-names>H</given-names> </name><name name-style="western"><surname>Abwao</surname><given-names>M</given-names> </name><name name-style="western"><surname>Baines</surname><given-names>A</given-names> </name></person-group><article-title>Social media use for health, cultural characteristics, and demographics: a survey of Pakistani millennials</article-title><source>Digit Health</source><year>2022</year><volume>8</volume><fpage>20552076221089454</fpage><pub-id pub-id-type="doi">10.1177/20552076221089454</pub-id><pub-id pub-id-type="medline">35401998</pub-id></nlm-citation></ref><ref id="ref32"><label>32</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Ho</surname><given-names>KF</given-names> </name><name name-style="western"><surname>Chang</surname><given-names>PC</given-names> </name><name name-style="western"><surname>Kurniasari</surname><given-names>MD</given-names> </name><name name-style="western"><surname>Susanty</surname><given-names>S</given-names> </name><name name-style="western"><surname>Chung</surname><given-names>MH</given-names> </name></person-group><article-title>Determining factors affecting nurses&#x2019; acceptance of a care plan system using a modified technology acceptance model 3: structural equation model with cross-sectional data</article-title><source>JMIR Med Inform</source><year>2020</year><month>05</month><day>5</day><volume>8</volume><issue>5</issue><fpage>e15686</fpage><pub-id pub-id-type="doi">10.2196/15686</pub-id><pub-id pub-id-type="medline">32369033</pub-id></nlm-citation></ref><ref id="ref33"><label>33</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Dearing</surname><given-names>JW</given-names> </name></person-group><article-title>Applying diffusion of innovation theory to intervention development</article-title><source>Res Soc Work Pract</source><year>2009</year><month>09</month><day>1</day><volume>19</volume><issue>5</issue><fpage>503</fpage><lpage>518</lpage><pub-id pub-id-type="doi">10.1177/1049731509335569</pub-id><pub-id pub-id-type="medline">20976022</pub-id></nlm-citation></ref><ref id="ref34"><label>34</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Zhang</surname><given-names>X</given-names> </name><name name-style="western"><surname>Yu</surname><given-names>P</given-names> </name><name name-style="western"><surname>Yan</surname><given-names>J</given-names> </name><name name-style="western"><surname>Ton A M Spil</surname><given-names>I</given-names> </name></person-group><article-title>Using diffusion of innovation theory to understand the factors impacting patient acceptance and use of consumer e-health innovations: a case study in a primary care clinic</article-title><source>BMC Health Serv Res</source><year>2015</year><month>02</month><day>21</day><volume>15</volume><fpage>71</fpage><pub-id pub-id-type="doi">10.1186/s12913-015-0726-2</pub-id><pub-id pub-id-type="medline">25885110</pub-id></nlm-citation></ref><ref id="ref35"><label>35</label><nlm-citation citation-type="book"><person-group person-group-type="author"><name name-style="western"><surname>Hair</surname><given-names>J</given-names> </name><name name-style="western"><surname>Hult</surname><given-names>G</given-names> </name><name name-style="western"><surname>Ringle</surname><given-names>C</given-names> </name><name name-style="western"><surname>Sarstedt</surname><given-names>M</given-names> </name></person-group><source>A Primer on Partial Least Squares Structural Equation Modeling (PLS-SEM)</source><year>2013</year><publisher-name>Sage Publications</publisher-name></nlm-citation></ref><ref id="ref36"><label>36</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Verdam</surname><given-names>MGE</given-names> </name><name name-style="western"><surname>Oort</surname><given-names>FJ</given-names> </name><name name-style="western"><surname>Sprangers</surname><given-names>MAG</given-names> </name></person-group><article-title>Using structural equation modeling to investigate change and response shift in patient-reported outcomes: practical considerations and recommendations</article-title><source>Qual Life Res</source><year>2021</year><month>05</month><volume>30</volume><issue>5</issue><fpage>1293</fpage><lpage>1304</lpage><pub-id pub-id-type="doi">10.1007/s11136-020-02742-9</pub-id><pub-id pub-id-type="medline">33550541</pub-id></nlm-citation></ref><ref id="ref37"><label>37</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Venkatesh</surname><given-names>V</given-names> </name><name name-style="western"><surname>Davis</surname><given-names>FD</given-names> </name></person-group><article-title>A theoretical extension of the technology acceptance model: four longitudinal field studies</article-title><source>Manage Sci</source><year>2000</year><month>02</month><volume>46</volume><issue>2</issue><fpage>186</fpage><lpage>204</lpage><pub-id pub-id-type="doi">10.1287/mnsc.46.2.186.11926</pub-id></nlm-citation></ref><ref id="ref38"><label>38</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Venkatesh</surname><given-names>V</given-names> </name></person-group><article-title>Determinants of perceived ease of use: integrating control, intrinsic motivation, and emotion into the technology acceptance model</article-title><source>Information Systems Research</source><year>2000</year><month>12</month><volume>11</volume><issue>4</issue><fpage>342</fpage><lpage>365</lpage><pub-id pub-id-type="doi">10.1287/isre.11.4.342.11872</pub-id></nlm-citation></ref><ref id="ref39"><label>39</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Ho</surname><given-names>KF</given-names> </name><name name-style="western"><surname>Ho</surname><given-names>CH</given-names> </name><name name-style="western"><surname>Chung</surname><given-names>MH</given-names> </name></person-group><article-title>Theoretical integration of user satisfaction and technology acceptance of the nursing process information system</article-title><source>PLoS One</source><year>2019</year><volume>14</volume><issue>6</issue><fpage>e0217622</fpage><pub-id pub-id-type="doi">10.1371/journal.pone.0217622</pub-id><pub-id pub-id-type="medline">31163076</pub-id></nlm-citation></ref><ref id="ref40"><label>40</label><nlm-citation citation-type="book"><person-group person-group-type="author"><name name-style="western"><surname>Hair</surname><given-names>J</given-names> </name></person-group><source>Multivariate Data Analysis</source><year>2006</year><access-date>2024-08-21</access-date><publisher-name>Pearson Prentice Hall</publisher-name><comment><ext-link ext-link-type="uri" xlink:href="https://drnishikantjha.com/papersCollection/Multivariate%20Data%20Analysis.pdf">https://drnishikantjha.com/papersCollection/Multivariate%20Data%20Analysis.pdf</ext-link></comment></nlm-citation></ref><ref id="ref41"><label>41</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Churchill</surname><given-names>GA</given-names> </name></person-group><article-title>A paradigm for developing better measures of marketing constructs</article-title><source>Journal of Marketing Research</source><year>1979</year><month>02</month><volume>16</volume><issue>1</issue><fpage>64</fpage><lpage>73</lpage><pub-id pub-id-type="doi">10.1177/002224377901600110</pub-id></nlm-citation></ref><ref id="ref42"><label>42</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Anderson</surname><given-names>JC</given-names> </name><name name-style="western"><surname>Gerbing</surname><given-names>DW</given-names> </name></person-group><article-title>The meffect of sampling error on convergence, improper solutions, and goodness-of-fit indices for maximum likelihood confirmatory factor analysis</article-title><source>Psychometrika</source><year>1984</year><month>06</month><volume>49</volume><issue>2</issue><fpage>155</fpage><lpage>173</lpage><pub-id pub-id-type="doi">10.1007/BF02294170</pub-id></nlm-citation></ref></ref-list><app-group><supplementary-material id="app1"><label>Multimedia Appendix 1</label><p>Questionnaire.</p><media xlink:href="humanfactors_v12i1e65745_app1.docx" xlink:title="DOCX File, 19 KB"/></supplementary-material><supplementary-material id="app2"><label>Multimedia Appendix 2</label><p>Additional tables.</p><media xlink:href="humanfactors_v12i1e65745_app2.docx" xlink:title="DOCX File, 17 KB"/></supplementary-material></app-group></back></article>