%0 Journal Article %@ 2292-9495 %I JMIR Publications %V 12 %N %P e58377 %T Factors Determining Acceptance of Internet of Things in Medical Education: Mixed Methods Study %A Alhumaid,Khadija %A Ayoubi,Kevin %A Khalifa,Maha %A Salloum,Said %K collaborative learning %K student %K college %K university %K education %K Internet of Things %K IoT %K technology acceptance model %K technology optimism %K TAM %K experience %K attitude %K opinion %K perception %K perspective %K acceptance %K adoption %K survey %K questionnaire %K ANN %K deep learning %K structural equation modeling %K neural network %K intent %K use %K medical education %K artificial neural network %K technology innovation %D 2025 %7 10.4.2025 %9 %J JMIR Hum Factors %G English %X Background: The global increase in the Internet of Things (IoT) adoption has sparked interest in its application within the educational sector, particularly in colleges and universities. Previous studies have often focused on individual attitudes toward IoT without considering a multiperspective approach and have overlooked the impact of IoT on the technology acceptance model outside the educational domain. Objective: This study aims to bridge the research gap by investigating the factors influencing IoT adoption in educational settings, thereby enhancing the understanding of collaborative learning through technology. It seeks to elucidate how IoT can facilitate learning processes and technology acceptance among college and university students in the United Arab Emirates. Methods: A questionnaire was distributed to students across various colleges and universities in the United Arab Emirates, garnering 463 participants. The data collected were analyzed using a hybrid approach that integrates structural equation modeling (SEM) and artificial neural network (ANN), along with importance-performance map analysis to evaluate the significance and performance of each factor affecting IoT adoption. Results: The study, involving 463 participants, identifies 2 primary levels at which factors influence the intention to adopt IoT technologies. Initial influences include technology optimism (TOP), innovation, and learning motivation, crucial for application engagement. Advanced influences stem from technology acceptance model constructs, particularly perceived ease of use (PE) and perceived usefulness (PU), which directly enhance adoption intentions. Detailed statistical analysis using partial least squares–SEM reveals significant relationships: TOP and innovativeness impact PE (β=.412, P=.04; β=.608, P=.002, respectively), and PU significantly influences TOP (β=.381, P=.04), innovativeness (β=.557, P=.003), and learning motivation (β=.752, P<.001). These results support our hypotheses (H1, H2, H3, H4, and H5). Further, the intention to use IoT is significantly affected by PE and usefulness (β=.619, P<.001; β=.598, P<.001, respectively). ANN modeling enhances these findings, showing superior predictive power (R2=89.7%) compared to partial least squares–SEM (R2=86.3%), indicating a more effective identification of nonlinear associations. Importance-performance map analysis corroborates these results, demonstrating the importance and performance of PU as most critical, followed by technology innovativeness and optimism, in shaping behavioral intentions to use IoT. Conclusions: This research contributes methodologically by leveraging deep ANN architecture to explore nonlinear relationships among factors influencing IoT adoption in education. The study underscores the importance of both intrinsic motivational factors and perceived technological attributes in fostering IoT adoption, offering insights for educational institutions considering IoT integration into their learning environments. %R 10.2196/58377 %U https://humanfactors.jmir.org/2025/1/e58377 %U https://doi.org/10.2196/58377