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Assuming a 50% response rate to stage 1 treatments (n=240) and a 20% attrition rate, approximately 48 participants will be eligible to be randomized to each of the 4 stage 2 treatment conditions (B, C, E, and F).
JMIR Res Protoc 2025;14:e68441
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At heart (formerly HEARTPA♀N) [29], a self-management progressive web application, was developed for women with CAD using a sequential phased approach recommended by the Medical Research Council (MRC) [30-32]. In phase 1, an integrated mixed methods systematic review was conducted to evaluate the current evidence related to the self-management of cardiac pain and associated symptoms (eg, dyspnea and fatigue) in women [7,29].
JMIR Hum Factors 2025;12:e57583
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A total of 360 Black young adults were included in this study, of whom 76% (n=272) identified as cisgender or transgender women. The median age was 24 (IQR 21‐27) years, and approximately one-third of participants (n=122) had a bachelor’s degree or higher. Overall vaccine uptake at month 3 was low (n=21) and did not significantly differ between the intervention and control arms (odds ratio [OR] 1.88, 95% CI 0.76 to 4.69).
JMIR Public Health Surveill 2025;11:e67370
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Mental Health Apps Available in App Stores for Indian Users: Protocol for a Systematic Review
Features of interactive self-care apps (N=33) were reviewed further, and this exercise showed that less than 10% of the apps incorporated explicit delineation of their scope or initial screening for suitability. Slightly more than one-third of these apps included content aimed at encouraging professional help-seeking when needed or an explicit mention of their theoretical or empirical basis. Challenges for potential users were highlighted [20].
JMIR Res Protoc 2025;14:e71071
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The 10 most frequent cancer diagnoses included prostate cancer (n=2476, 13.8%); breast cancer (n=2006, 11.2%); malignant melanoma of the skin (n=1921, 10.7%); cancer of the trachea, bronchus, and lungs (n=1415, 7.9%); cancer of the lip, oral cavity, and pharynx (n=1329, 7.4%); and cancer of the colon and rectum (n=1187, 6.6%). Non-Hodgkin lymphoma (n=801), cervical cancer (n=719), pancreatic cancer (n=644), and thyroid cancer each accounted for 4%.
J Med Internet Res 2025;27:e65681
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We evaluate the number of clinics and number of patients, assuming that MPACT intervention reduces this frequency to 45% (n=240), 50% (n=300), and 55% (n=330). The power curves based on independent observations (no cluster effect) are shown in Figure 3. The graph shows that the recruitment of 30 clinics, with 20 patients per clinic, provides greater than 80% power to detect a difference in treatment interruption rates of 66% (control) and 55% (MPACT) with α=.05.
JMIR Res Protoc 2025;14:e69829
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Given the anticipated overlap of these conditions, ≈20% (n=90) of women will have at least one maternal metabolic disease of interest (secondary outcome).
Study data are collected using paper case report forms. These paper documents will be kept in a locked cupboard accessible only to local research staff. Patient information is collected and stored by the investigators in a confidential REDCap (Research Electronic Data Capture system; Vanderbilt University), with password protection and restricted access.
JMIR Res Protoc 2025;14:e72542
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We reviewed 102 surgical pathology reports from 102 patients and excluded reports if they were from other organ sites (n=10), benign (n=2), cytopathology (n=5), or outside review (n=1). We included 84 reports for analysis. The study flowchart is shown in Figure 2.
Flowchart of the study design and analysis. *The concordance rate was calculated as the total number of concordant answers/total number of answers for each of the 12 medical question answering (MQA).
JMIR Form Res 2025;9:e64544
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Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap Map
A much smaller number of studies (n=6) examined the utility of VR in chronic pain populations including intensive pain rehabilitation (n=1) [112], chronic burn dressing (n=1) [113], chronic musculoskeletal pain (n=1) [114], chronic cancer-related pain (n=2) [115,116], and chronic abdominal pain (n=1) [117]. See Figure 2 for the summary of pain populations included across the studies.
JMIR Pediatr Parent 2025;8:e63854
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We have randomized 22 administrative wards in a 1:1 ratio and aim to enroll about 72 adolescent girls and young women from each (total N=about 1584) to receive either the Tu’Washindi intervention plus usual HIV prevention services, or usual HIV prevention services alone.
JMIR Res Protoc 2025;14:e55931
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