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Unraveling Online Mental Health Through the Lens of Early Maladaptive Schemas: AI-Enabled Content Analysis of Online Mental Health Communities

Unraveling Online Mental Health Through the Lens of Early Maladaptive Schemas: AI-Enabled Content Analysis of Online Mental Health Communities

A key contribution of this study is the novel group-level case conceptualization technique, which uses recent advanced LLMs and prompt engineering techniques to extract EMS features from OMHC posts. This approach provides valuable insights into how EMSs are expressed in online support-seeking environments and has the potential to inform personalized, ST-focused interventions.

Beng Heng Ang, Sujatha Das Gollapalli, Mingzhe Du, See-Kiong Ng

J Med Internet Res 2025;27:e59524

Efficacy and Safety of Murivenna Anal Infiltration Compared to Diltiazem Topical Application in Chronic Anal Fissure: Protocol for a Prospective, Randomized, Open-Label Clinical Trial

Efficacy and Safety of Murivenna Anal Infiltration Compared to Diltiazem Topical Application in Chronic Anal Fissure: Protocol for a Prospective, Randomized, Open-Label Clinical Trial

Miscellaneous novel therapies such as sacral nerve stimulation, autologous adipose tissue transplantation, and posterior tibial nerve stimulation are now being examined as alternatives to lateral sphincterotomy and reliable procedures to avoid fecal incontinence [7]. However, pharmacological modalities are more preferred for treatment of anal fissure, as they are well tolerated, with minimal to no side effects.

Pratap Shankar KM, Indu Puthan Purayil, Palengara Binitha, Amit Kumar Rai, Sophia Jameela, Azeem Ahmad, Chandra Sekhara Rao Bhogavalli, Narayanam Srikanth, Rabinarayan Acharya

JMIR Res Protoc 2025;14:e63063

Two-Layer Retrieval-Augmented Generation Framework for Low-Resource Medical Question Answering Using Reddit Data: Proof-of-Concept Study

Two-Layer Retrieval-Augmented Generation Framework for Low-Resource Medical Question Answering Using Reddit Data: Proof-of-Concept Study

Recently, Reddit data have been leveraged to study novel psychoactive substances since such information is not typically available elsewhere. We chose two substances that have gained attention recently—xylazine (because of its increasing impact and association with the US opioid crisis) and ketamine (because of its recent popularity as a treatment for depression).

Sudeshna Das, Yao Ge, Yuting Guo, Swati Rajwal, JaMor Hairston, Jeanne Powell, Drew Walker, Snigdha Peddireddy, Sahithi Lakamana, Selen Bozkurt, Matthew Reyna, Reza Sameni, Yunyu Xiao, Sangmi Kim, Rasheeta Chandler, Natalie Hernandez, Danielle Mowery, Rachel Wightman, Jennifer Love, Anthony Spadaro, Jeanmarie Perrone, Abeed Sarker

J Med Internet Res 2025;27:e66220