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The primary goal of aim 1 is to identify the most effective ATS among the 4 embedded strategies (A+B, A+C, D+E, or D+F, as shown in Table 2) that leads to the greatest reduction in STB. This aim focuses on finding the best-performing ATS rather than testing a hypothesis. The sample size of 480 was found to ensure an 80% probability of correctly identifying the ATS with the lowest mean outcome, assuming that such a strategy exists.
JMIR Res Protoc 2025;14:e68441
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From the extended-cosine models, we extracted measures of 24-hour robustness (pseudo-F statistic, indicating how well the observed data fits the 24-hour curve); activity onset time (up-mesor, the time which the modeled activity level passes the middle modeled rhythm height prior to the peak); and activity offset time (down-mesor or the time which the modeled activity level passes the middle modeled rhythm height prior to the nadir).
JMIR Aging 2025;8:e67294
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Unintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial
JMIR Res Protoc 2025;14:e72032
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The study complied with the 1964 Helsinki Declaration and its later amendments and was approved by the Ethics Committee of the Lega F. D’Oro, Osimo (AN), Italy (P030820241).
Figures 2 reports the data for Liam, Hallie, Logan, and Kali and Figure 3 reports the data for Harper, Jacob, Millie, and Isabel over the different phases of the study. Each data point represents the mean frequency of responses per session over a block (group) of sessions.
JMIR Rehabil Assist Technol 2025;12:e70378
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