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Detecting Sleep/Wake Rhythm Disruption Related to Cognition in Older Adults With and Without Mild Cognitive Impairment Using the myRhythmWatch Platform: Feasibility and Correlation Study

Detecting Sleep/Wake Rhythm Disruption Related to Cognition in Older Adults With and Without Mild Cognitive Impairment Using the myRhythmWatch Platform: Feasibility and Correlation Study

Even among adults with normal cognition, rhythm fragmentation correlates with greater brain amyloid deposition [3,4]. Over time, 24-hour rhythm fragmentation has been associated with increased risk and faster rates of cognitive decline in people with MCI and mild-to-moderate dementia [1,5] .

Caleb D Jones, Rachel Wasilko, Gehui Zhang, Katie L Stone, Swathi Gujral, Juleen Rodakowski, Stephen F Smagula

JMIR Aging 2025;8:e67294

Investigating Measurement Equivalence of Smartphone Sensor–Based Assessments: Remote, Digital, Bring-Your-Own-Device Study

Investigating Measurement Equivalence of Smartphone Sensor–Based Assessments: Remote, Digital, Bring-Your-Own-Device Study

The Floodlight Open app was designed to remotely measure, in a naturalistic setting, functional ability in cognition, hand motor function, gait and balance, mobility, and mood through smartphone-based active tests, passively collected life-space measurements, and patient-reported outcomes. The individual tests have been previously described [33]. It supports all devices running i OS version 11.x or later or Android version 7.x or later, which were commonly available at the time the app was launched.

Lito Kriara, Frank Dondelinger, Luca Capezzuto, Corrado Bernasconi, Florian Lipsmeier, Adriano Galati, Michael Lindemann

J Med Internet Res 2025;27:e63090

Digital Assessment of Cognitive Health in Outpatient Primary Care: Usability Study

Digital Assessment of Cognitive Health in Outpatient Primary Care: Usability Study

Near-term and delayed cognition-relevant orders placed following the administration of the Core Cognitive Evaluation (CCE). a CT: computed tomography. b MRI: magnetic resonance imaging. c PET: positron emission tomography. The results of the preassessment survey for patients and caregivers are displayed in Table 3, and the stratified results are shown in Table S1 in Multimedia Appendix 1.

Adam J Doerr, Taylor A Orwig, Matthew McNulty, Stephanie Denise M Sison, David R Paquette, Robert Leung, Huitong Ding, Stephen B Erban, Bruce R Weinstein, Yurima Guilarte-Walker, Adrian H Zai, Allan J Walkey, Apurv Soni, David D McManus, Honghuang Lin

JMIR Form Res 2025;9:e66695

Effects of a Mobile Health Intervention Based on Behavioral Integrated Model on Cognitive and Behavioral Changes in Gestational Weight Management: Randomized Controlled Trial

Effects of a Mobile Health Intervention Based on Behavioral Integrated Model on Cognitive and Behavioral Changes in Gestational Weight Management: Randomized Controlled Trial

A higher total score indicated better psychological cognition among pregnant women. The total Cronbach α for the cognition scale of 0.860, ranged from 0.822 to 0.938. (3) Gestational weight management behavioral scales included 4 dimensions encompassing 20 items, each item was rated on a 5-point Likert scale ranging from 1 (never) to 5 (always).

Meng Zhou, Li Wang, Ying Deng, Jinjin Ge, Shiqi Zhao, Hua You

J Med Internet Res 2025;27:e55844

Tablet- and Group-Based Multicomponent Cognitive Stimulation for Older Adults With Mild Cognitive Impairment: Single-Group Pilot Study and Protocol for Randomized Controlled Trial

Tablet- and Group-Based Multicomponent Cognitive Stimulation for Older Adults With Mild Cognitive Impairment: Single-Group Pilot Study and Protocol for Randomized Controlled Trial

Furthermore, Silva and colleagues [15] discovered that in MCI or mild dementia, a cognitive stimulation program could account for the improved cognition response observed. These data reveal that the lower the cognitive damage, the better the neuroplastic capacity and ability to learn, and the greater the potential to induce neurogenesis. Therefore, cognitive interventions should be implemented at the earliest stages of cognitive impairment [15].

Khanitin Jornkokgoud, Pattrawadee Makmee, Peera Wongupparaj, Alessandro Grecucci

JMIR Res Protoc 2025;14:e64465

Digital Migration of the Loewenstein Acevedo Scales for Semantic Interference and Learning (LASSI-L): Development and Validation Study in Older Participants

Digital Migration of the Loewenstein Acevedo Scales for Semantic Interference and Learning (LASSI-L): Development and Validation Study in Older Participants

In addition, at the LASSI assessment for both cohorts, we administered several standard cognitive measures used for staging AD/ADRD, including immediate and delayed paragraph recall [28], the Hopkins Verbal Learning Test-revised [29], and Alzheimer Disease Assessment Scale-Cognition (ADAS-Cog) [30]. Our overall study goals were to examine convergence of the LASSI-D form A with standard administration, and the LASSI-L, in terms of performance.

Philip Harvey, Rosie Curiel-Cid, Peter Kallestrup, Annalee Mueller, Andrea Rivera-Molina, Sara Czaja, Elizabeth Crocco, David Loewenstein

JMIR Ment Health 2025;12:e64716

A New Computer-Based Cognitive Measure for Early Detection of Dementia Risk (Japan Cognitive Function Test): Validation Study

A New Computer-Based Cognitive Measure for Early Detection of Dementia Risk (Japan Cognitive Function Test): Validation Study

Further studies may require the use of digital cognitive biomarkers in long-term follow-up to monitor the conversion from normal cognition to dementia. We developed a digital cognitive test, the Japanese Cognitive Function Test (J-Cog), which assesses orientation, verbal ability, attention, visuospatial performance, reasoning, and memory, to identify older adults with cognitive impairment in primary settings.

Hiroyuki Shimada, Takehiko Doi, Kota Tsutsumimoto, Keitaro Makino, Kenji Harada, Kouki Tomida, Masanori Morikawa, Hyuma Makizako

J Med Internet Res 2025;27:e59015