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Augmenting Insufficiently Accruing Oncology Clinical Trials Using Generative Models: Validation Study

Augmenting Insufficiently Accruing Oncology Clinical Trials Using Generative Models: Validation Study

Approximately, 25% of clinical trials are discontinued before completion [3], with insufficient recruitment being the most frequent reason in 31% of the cases [4]. For adult cancer trials, between 20% and 50% fail to complete or were unable to reach recruitment goals [5-9]. This has been exacerbated by the recent pandemic where many trials experienced a considerable reduction in recruitment rates [10-13], which has continued after the pandemic [12].

Samer El Kababji, Nicholas Mitsakakis, Elizabeth Jonker, Ana-Alicia Beltran-Bless, Gregory Pond, Lisa Vandermeer, Dhenuka Radhakrishnan, Lucy Mosquera, Alexander Paterson, Lois Shepherd, Bingshu Chen, William Barlow, Julie Gralow, Marie-France Savard, Christian Fesl, Dominik Hlauschek, Marija Balic, Gabriel Rinnerthaler, Richard Greil, Michael Gnant, Mark Clemons, Khaled El Emam

J Med Internet Res 2025;27:e66821

Assessing Health Information Seeking Behaviors Among Targeted Social Media Users Using an Infotainment Video About a Cancer Clinical Trial: Population-Based Descriptive Study

Assessing Health Information Seeking Behaviors Among Targeted Social Media Users Using an Infotainment Video About a Cancer Clinical Trial: Population-Based Descriptive Study

Although research organizations have passively disseminated clinical trial–related content on social media platforms, this very active and intentional campaign to engage with the public is promising as it relates to clinical trial recruitment and illustrates the utility of using engaging digital content coupled with social media marketing as an effective strategy for clinical trial recruitment.

Jonathan Sommers, Don S Dizon, Mark A Lewis, Erik Stone, Richard Andreoli, Vida Henderson

JMIR Cancer 2025;11:e56098

Enhancing Text Message Support With Media Literacy and Financial Incentives for Vaping Cessation in Young Adults: Protocol for a Pilot Randomized Controlled Trial

Enhancing Text Message Support With Media Literacy and Financial Incentives for Vaping Cessation in Young Adults: Protocol for a Pilot Randomized Controlled Trial

If the recruitment goal of 80 participants is not met after exhausting the initial participant list, the research team will directly contact potential participants via phone calls. In addition, we will implement a social media recruitment strategy by posting study advertisements on platforms such as Facebook (Meta), Instagram (Meta), or X (formerly Twitter).

Tzeyu Michaud, Troy Puga, Rex Archer, Elijah Theye, Cleo Zagurski, Paul Estabrooks, Hongying Daisy Dai

JMIR Res Protoc 2025;14:e60527

Detecting Deception and Ensuring Data Integrity in a Nationwide mHealth Randomized Controlled Trial: Factorial Design Survey Study

Detecting Deception and Ensuring Data Integrity in a Nationwide mHealth Randomized Controlled Trial: Factorial Design Survey Study

Given the relatively large scale of our digitally mediated recruitment methods, the low risk involved in study participation, considerable financial compensation, and robust practices for ultimately verifying participants’ identity, this study provided unique insight into how deceptive practices may be occurring in large, remotely delivered behavioral studies, as well as how to mitigate their impact.

Krista M Kezbers, Michael C Robertson, Emily T Hébert, Audrey Montgomery, Michael S Businelle

J Med Internet Res 2025;27:e66384

Recruiting Young People for Digital Mental Health Research: Lessons From an AI-Driven Adaptive Trial

Recruiting Young People for Digital Mental Health Research: Lessons From an AI-Driven Adaptive Trial

However, compared to traditional randomized controlled trials (RCTs), AI-adaptive trials face an increased risk of insufficient and untimely enrollment due to the need for frequent, short-spanned recruitment drives (eg, monthly recruitment drives over a year). Hence, identifying recruitment methodologies that are both cost-effective and time-efficient is crucial for the success of such trials. What recruitment methods are currently used and how do they compare with each other?

Wu Yi Zheng, Artur Shvetcov, Aimy Slade, Zoe Jenkins, Leonard Hoon, Alexis Whitton, Rena Logothetis, Smrithi Ravindra, Stefanus Kurniawan, Sunil Gupta, Kit Huckvale, Eileen Stech, Akash Agarwal, Joost Funke Kupper, Stuart Cameron, Jodie Rosenberg, Nicholas Manoglou, Manisha Senadeera, Svetha Venkatesh, Kon Mouzakis, Rajesh Vasa, Helen Christensen, Jill M Newby

J Med Internet Res 2025;27:e60413

Recruitment of Young Gay, Bisexual, and Other Men Who Have Sex With Men for a Web-Based Human Papillomavirus Vaccination Intervention: Differences in Participant Characteristics and Study Engagement by Recruitment Source in a Randomized Controlled Trial

Recruitment of Young Gay, Bisexual, and Other Men Who Have Sex With Men for a Web-Based Human Papillomavirus Vaccination Intervention: Differences in Participant Characteristics and Study Engagement by Recruitment Source in a Randomized Controlled Trial

Gay, bisexual, and other men who have sex with men have previously been referred to as a “hard-to-reach” or “hidden” population for study recruitment [12,13], and traditional recruitment approaches for this community often included snowball sampling, use of “gatekeeper” organizations associated with the community, and venue-based recruitment at community events, health clinics, or other settings [11,14,15].

Daniel J Marshall, Amy L Gower, Mira L Katz, José A Bauermeister, Abigail B Shoben, Paul L Reiter

J Med Internet Res 2025;27:e64668

Social Media Recruitment as a Potential Trigger for Vulnerability: Multistakeholder Interview Study

Social Media Recruitment as a Potential Trigger for Vulnerability: Multistakeholder Interview Study

One potential factor that might aggravate—or mitigate—vulnerability in the research context is using social media as a recruitment channel for research studies. On the one hand, social media recruitment allows for effective reaching of populations that are challenging to reach through other recruitment channels since social media have targeted advertising features that enable researchers to tailor recruitment efforts to specific characteristics, interests, and behaviors.

Nina Matthes, Theresa Willem, Alena Buyx, Bettina M Zimmermann

JMIR Hum Factors 2024;11:e52448

From Doubt to Confidence—Overcoming Fraudulent Submissions by Bots and Other Takers of a Web-Based Survey

From Doubt to Confidence—Overcoming Fraudulent Submissions by Bots and Other Takers of a Web-Based Survey

In addition, researchers can create an original sample of web-based survey participants through recruitment strategies such as ads on social media platforms. Each of the 3 options for sourcing participants has relative strengths and trade-offs in terms of the required effort from the research team, cost, speed of recruitment, data quality, maximum sample size, and representativeness of the target sample.

Jeffrey J Hardesty, Elizabeth Crespi, Joshua K Sinamo, Qinghua Nian, Alison Breland, Thomas Eissenberg, Ryan David Kennedy, Joanna E Cohen

J Med Internet Res 2024;26:e60184

Recruitment of Adolescents to Virtual Clinical Trials: Recruitment Results From the Health4Me Randomized Controlled Trial

Recruitment of Adolescents to Virtual Clinical Trials: Recruitment Results From the Health4Me Randomized Controlled Trial

The use of digital methods for recruitment to clinical trials is increasing in popularity and they are particularly beneficial for recruitment to online clinical trials. Previous research has focused on comparing social media or other digital strategies to traditional in-person recruitment [8-13], and the use of digital tools for recruitment and retention of clinical trial participants [14,15].

Rebecca Raeside, Allyson R Todd, Sarah Barakat, Sean Rom, Stephanie Boulet, Sarah Maguire, Kathryn Williams, Seema Mihrshahi, Maree L Hackett, Julie Redfern, Stephanie R Partridge, The Health4Me Team, The Health4Me Team

JMIR Pediatr Parent 2024;7:e62919

Data Verification and Respondent Validity for a Web-Based Sexual Health Survey: Tutorial

Data Verification and Respondent Validity for a Web-Based Sexual Health Survey: Tutorial

There is limited academic literature that describes the best practices for ensuring data verification from web-based or social media–based (eg, Facebook, Instagram) recruitment for health surveys [10,17,18]. We aim to explain the processes of ensuring data verification and a representative sample through social media recruitment for a survey-based study by sharing the steps of instrument design, programming, and data verification that resulted in our final sample.

Jayelin N Parker, Theresa L Rager, Jade Burns, Okeoma Mmeje

JMIR Form Res 2024;8:e56788