Mobile Therapeutic Attention for Treatment-Resistant Schizophrenia (m-RESIST) Solution for Improving Clinical and Functional Outcomes in Treatment-Resistant Schizophrenia: Prospective, Multicenter Efficacy Study

Jussi Seppälä   ^{1, 2} , MD, PhD ;   Eva Grasa   ^{3, 4} , PhD ;   Anna Alonso-Solis   ^{4, 5} , PhD ;   Alexandra Roldan-Bejarano   ^{3, 4} , MD, PhD ;   Marianne Haapea   ^{2, 6, 7} , PhD ;   Matti Isohanni   ² , MD, PhD ;   Jouko Miettunen   ^{2, 6} , PhD ;   Johanna Caro Mendivelso   ⁸ , MD, PhD ;   Cari Almazán   ⁸ , MD ;   Katya Rubinstein   ⁹ , PhD ;   Asaf Caspi   ⁹ , MD ;   Zolt Unoka   ¹⁰ , MD ;   Kinga Farkas   ¹⁰ , MD, PhD ;   Elisenda Reixach   ¹¹ , PhD ;   Jesus Berdun   ¹² , MSc ;   Judith Usall   ^{4, 13, 14} , MD, PhD ;   Susana Ochoa   ^{4, 13, 14} , PhD ;   Iluminada Corripio   ^{4, 15, 16 *} , MD, PhD ;   Erika Jääskeläinen   ^{17 *} , MD, PhD ;   m-Resist Group  

¹ Social Insurance Institution of Finland, Kuopio, Finland

² Research Unit of Population Health, University of Oulu, Oulu, Finland

³ Mental Health, Institut de Recerca Sant Pau IR SANT PAU, SantQuintí 77-79, Barcelona, Spain

⁴ Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Madrid, Spain

⁵ Mental Health Division, Fundació Althaia, Xarxa Assistencial Universitaria de Manresa, Manresa, Spain

⁶ Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland

⁷ Department of Psychiatry, Oulu University Hospital, Oulu, Finland

⁸ Agency for Health Quality and Assessment of Catalonia AQuAS, Barcelona, Spain

⁹ The Gertner Institute of Epidemiology and Health Policy Research, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel

¹⁰ Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary

¹¹ TicSalut Health Department, Generalitat de Catalunya, Barcelona, Spain

¹² Digital Health Unit, Hospital de la Santa Creu i Sant Pau, Institut d’Investigació Biomèdica Sant Pau IIB SANT PAU, Barcelona, Spain

¹³ Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain

¹⁴ Etiopatogènia i tractament dels trastorns mentals greus MERITT, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain

¹⁵ Mental Health and Psychiatry Department, Vic Hospital Consortium, Vic, Spain

¹⁶ Mental Health, Institut de Recerca Sant Pau IR SANT PAU, Barcelona, Spain

¹⁷ Unit of Population Health, University of Oulu, Oulu, Finland

*these authors contributed equally