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Online Information About Side Effects and Safety Concerns of Semaglutide: Mixed Methods Study of YouTube Videos

Online Information About Side Effects and Safety Concerns of Semaglutide: Mixed Methods Study of YouTube Videos

The use of semaglutide, particularly the famous Ozempic, by nonsevere overweight individuals might pose safety issues [24]. Off-label drug use is legal and common, though it means a drug is being used for an unapproved indication or population, at an unapproved dosage, or via an unapproved route of administration [24,25]. Off-label users may have a higher safety risk if they obtain semaglutide via online vendors or beauty spas without a proper medical consultation [26].

Andy Wai Kan Yeung, Fabian Peter Hammerle, Sybille Behrens, Maima Matin, Michel-Edwar Mickael, Olena Litvinova, Emil D Parvanov, Maria Kletecka-Pulker, Atanas G Atanasov

JMIR Infodemiology 2025;5:e59767

Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap Map

Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap Map

Therefore, the purpose of this systematic review was to describe the feasibility, safety, and effectiveness of XR for pediatric acute and chronic pain. Moreover, this review collated current research to establish an evidence and gap map for guiding future research efforts. Finally, given the variability in XR study treatment outcomes, this review also assessed the measurement tools that have been used to measure outcomes in XR research.

Courtney W Hess, Brittany N Rosenbloom, Giulia Mesaroli, Cristal Lopez, Nhat Ngo, Estreya Cohen, Carley Ouellette, Jeffrey I Gold, Deirdre Logan, Laura E Simons, Jennifer N Stinson

JMIR Pediatr Parent 2025;8:e63854

The Dynamics of Doctor-Patient Communication During Remote Consultations: Qualitative Study Among Norwegian Contract General Practitioners

The Dynamics of Doctor-Patient Communication During Remote Consultations: Qualitative Study Among Norwegian Contract General Practitioners

Although being of beneficial use in relation to clear reasons for contact, their safety hinges on patients’ ability to articulate their complaints. Strategic preservation of continuity of care emerges as crucial in mitigating the identified challenges. A central finding in our study is that the observed changes in communication during remote consultations are not primarily associated with specific reasons for contact.

Børge Lønnebakke Norberg, Bjarne Austad, Eli Kristiansen, Paolo Zanaboni, Linn Okkenhaug Getz

J Med Internet Res 2025;27:e57679

Consumer Engagement With Risk Information on Prescription Drug Social Media Pages: Findings From In-Depth Interviews

Consumer Engagement With Risk Information on Prescription Drug Social Media Pages: Findings From In-Depth Interviews

Pharmaceutical companies currently present risk information (often referred to as “safety information” in promotion) about the prescription drugs they promote in a variety of ways across social media platforms. For example, companies may use links to provide access to risk information, such as a link to the drug’s external website or a link to a PDF file with the full prescribing and medication guide.

Jacqueline B Amoozegar, Peyton Williams, Kristen C Giombi, Courtney Richardson, Ella Shenkar, Rebecca L Watkins, Amie C O'Donoghue, Helen W Sullivan

J Med Internet Res 2025;27:e67361

Values of Stakeholders Involved in Applying Surveillance Technology for People With Dementia in Nursing Homes: Scoping Review

Values of Stakeholders Involved in Applying Surveillance Technology for People With Dementia in Nursing Homes: Scoping Review

Staff’s desire to be helpful and respond to the needs of residents also partly overlapped with the value security, which is characterized by striving to assure the safety of loved ones, taking precautions to prevent harm, and being warned in case of threats [45]. From the nursing staff perspective, surveillance technologies were most often applied to enhance the general safety of residents, mitigate the risk of falling, alert staff promptly, and contribute to efficient care [7,22,46].

Daniëlle van Gaans-Riteco, Annerieke Stoop, Eveline Wouters

JMIR Aging 2025;8:e64074

Identifying Patient-Reported Care Experiences in Free-Text Survey Comments: Topic Modeling Study

Identifying Patient-Reported Care Experiences in Free-Text Survey Comments: Topic Modeling Study

Future studies could evaluate whether these topics could have relevance as part of broader indicators of patient safety. APIES respondents are the parents or caregivers of pediatric patients and reflect the experiences and priorities of both the patient and their family.

Brian Steele, Paul Fairie, Kyle Kemp, Adam G D'Souza, Matthias Wilms, Maria Jose Santana

JMIR Med Inform 2025;13:e63466

Exergame (ExerG)-Based Physical-Cognitive Training for Rehabilitation in Adults With Motor and Balance Impairments: Usability Study

Exergame (ExerG)-Based Physical-Cognitive Training for Rehabilitation in Adults With Motor and Balance Impairments: Usability Study

Key considerations include safety, training goals, individuality, game environment, social interactions, and physical and technical overload for patients, as well as facets like meaningfulness, distractions from the game environment, safety, gamification elements, and the availability and accessibility of the exergame for therapists [13]. Therefore, further investigation into the usability and user experience of exergame functional models in real-world rehabilitation settings is essential.

Silvia Herren, Barbara Seebacher, Sarah Mildner, Yanick Riederer, Ulrike Pachmann, Nija Sonja Böckler, Stephan Niedecken, Sabrina Alicia Sgandurra, Leo Bonati, Isabella Hotz, Alexandra Schättin, Roman Jurt, Christian Brenneis, Katharina Lenfert, Frank Behrendt, Stefan Schmidlin, Lennart Nacke, Corina Schuster-Amft, Anna Lisa Martin-Niedecken

JMIR Serious Games 2025;13:e66515

Telehealth-Based vs In-Person Aerobic Exercise in Individuals With Schizophrenia: Comparative Analysis of Feasibility, Safety, and Efficacy

Telehealth-Based vs In-Person Aerobic Exercise in Individuals With Schizophrenia: Comparative Analysis of Feasibility, Safety, and Efficacy

To address this gap in the literature, our aim was to examine the feasibility, safety, and efficacy of telehealth-based delivery of AE in this population. Data were obtained from a multi-site, single-blind, parallel-group, randomized clinical trial examining the impact of AE on neurocognition in individuals with schizophrenia (Clinical Trials.gov NCT03270098).

David Kimhy, Luz H Ospina, Melanie Wall, Daniel M Alschuler, Lars F Jarskog, Jacob S Ballon, Joseph McEvoy, Matthew N Bartels, Richard um Buchsba, Marianne Goodman, Sloane A Miller, T Scott Stroup

JMIR Ment Health 2025;12:e68251

The Effects of Presenting AI Uncertainty Information on Pharmacists’ Trust in Automated Pill Recognition Technology: Exploratory Mixed Subjects Study

The Effects of Presenting AI Uncertainty Information on Pharmacists’ Trust in Automated Pill Recognition Technology: Exploratory Mixed Subjects Study

In the context of pill dispensing, FAs may lead to minor disruptions, while misses could lead to dispensing errors, indicating that a more liberal AI system prioritizing safety by minimizing misses is beneficial. This study, therefore, aimed to explore pharmacists’ trust in automated pill verification technology, which is designed to assist with the critical task of medication dispensing. Specifically, we aimed to study the role of presenting AI uncertainty information on pharmacists’ trust in the system.

Jin Yong Kim, Vincent D Marshall, Brigid Rowell, Qiyuan Chen, Yifan Zheng, John D Lee, Raed Al Kontar, Corey Lester, Xi Jessie Yang

JMIR Hum Factors 2025;12:e60273

The Safety of Digital Mental Health Interventions: Findings and Recommendations From a Qualitative Study Exploring Users’ Experiences, Concerns, and Suggestions

The Safety of Digital Mental Health Interventions: Findings and Recommendations From a Qualitative Study Exploring Users’ Experiences, Concerns, and Suggestions

The expanding body of literature addressing the safety of DMHIs is noteworthy [1,5,6]. While considerable attention has been devoted to exploring the safety of DMHIs (how it is assessed, analyzed, and reported), a notable gap exists in the qualitative understanding of individual perspectives on the topic.

Rayan Taher, Daniel Stahl, Sukhi Shergill, Jenny Yiend

JMIR Hum Factors 2025;12:e62974