This paper is in the following e-collection/theme issue:

Psychological, Behavioral, Social, and/or Cultural Experiments and Interventions (95) Digital Mental Health Interventions, e-Mental Health and Cyberpsychology (2121) Chatbots and Conversational Agents (743) Generative Language Models Including ChatGPT (713) Anxiety and Stress Disorders (1331) Nursing Communication (30)

Published on in Vol 12 (2025)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/65785, first published .
Comparison of an AI Chatbot With a Nurse Hotline in Reducing Anxiety and Depression Levels in the General Population: Pilot Randomized Controlled Trial

Comparison of an AI Chatbot With a Nurse Hotline in Reducing Anxiety and Depression Levels in the General Population: Pilot Randomized Controlled Trial

Comparison of an AI Chatbot With a Nurse Hotline in Reducing Anxiety and Depression Levels in the General Population: Pilot Randomized Controlled Trial

Authors of this article:

Chen Chen1 Author Orcid Image ;   Kok Tai Lam1 Author Orcid Image ;   Ka Man Yip1 Author Orcid Image ;   Hung Kwan So1 Author Orcid Image ;   Terry Yat Sang Lum2 Author Orcid Image ;   Ian Chi Kei Wong3, 4, 5 Author Orcid Image ;   Jason C Yam6 Author Orcid Image ;   Celine Sze Ling Chui7 Author Orcid Image ;   Patrick Ip1 Author Orcid Image
Article Authors Cited by (8) Tweetations (10) Metrics

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  1. Indrayanti I, Salsabila A, Amrita V, Alhaddad M, Saskia A, Ramadhani D. PsyBot: A randomized controlled trial of WhatsApp-based psychological first aid to reduce loneliness among 18–22-year-old students in Yogyakarta, Indonesia. SSM - Mental Health 2025;8:100504 View
  2. Tomasz Ufniarski , Maria Ufniarska , Aleksandra Piech , Karolina Pasierb , Karol Poplicha , Martyna Grodzińska , Bartłomiej Siuzdak , Justyna Moszkowicz , Piotr Sobkiewicz , Patrycja Kardasz , Marta Jutrzenka , Patrycja Ucieklak . LARGE LANGUAGE MODEL BASED CHATBOTS – A CHANCE FOR CLOSING THE MENTAL HEALTH TREATMENT GAP OR A THREAT TO THE PUBLIC HEALTH? A NARRATIVE REVIEW. International Journal of Innovative Technologies in Social Science 2025;3(3(47)) View
  3. Misiak B, Karska J, Kowalski S, Courtet P, Volpe U, Schouler-Ocak M, Destoop M, Adorjan K, Kraxner F, Buwalda V, Campion J, Beezhold J, Falkai P, Dom G. Urban mental health: a position paper of the European psychiatric association. European Psychiatry 2025;68(1) View
  4. Bodner R, Lim K, Schneider R, Torous J. Efficacy and risks of artificial intelligence chatbots for anxiety and depression: a narrative review of recent clinical studies. Current Opinion in Psychiatry 2026;39(1):19 View
  5. Zhang Q, Zhang R, Xiong Y, Sui Y, Tong C, Lin F. Generative AI Mental Health Chatbots as Therapeutic Tools: A Systematic Review and Meta-Analysis of their Role in Reducing Mental Health Issues (Preprint). Journal of Medical Internet Research 2025 View
  6. Watson A, Bond C, Aveyard H, Smith G, Jackson D. Generative AI at the Bedside: An Integrative Review of Applications and Implications in Clinical Nursing Practice. Journal of Clinical Nursing 2025 View
  7. Liu Q, Liu S, Si G, Cui K. Which voice aids mental health interactions? Exploring dual-pathway effects of voice anthropomorphism of AI health chatbots on patient anxiety. Industrial Management & Data Systems 2025:1 View
  8. Du Q, Ren Y, Meng Z, He H, Meng S. The Efficacy of Rule-Based Versus Large Language Model-Based Chatbots in Alleviating Symptoms of Depression and Anxiety: Systematic Review and Meta-Analysis. Journal of Medical Internet Research 2025;27:e78186 View